Journal of Skin and Stem Cell

Uncorrected Proof scheduled for 3 (4)

31/12/2016

Research Article

Discovering Cellular Response to Medicinal Herbs, Iranian Traditional Medicine and Modern Cosmeceutical Approaches

Fatemeh Salehinia, Hamidreza Ahmadi Ashtiani, Hossein Rastegar, Abdol-Amir Allameh, Sona Zare, Mohammad Ali Nilforoushzadeh

DOI: 10.5812/jssc.66532

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Introduction: Fibroblasts are the most prominent cells of the skin. Consequently, skin aging depends predominantly on these cells. Applying herbs in anti-aging, antioxidant, anti-pollutant, anti-bacterial, and anti-inflammatory formulas are now growing. On the basis of the fact that Iranian traditional medicine has utilized herbs for several centuries in order to improve various kinds of health issues, Rosemarinus officinalis leaf extract and Altheae officinalis root extract have been selected for evaluating their effects on viability and proliferation on HDF in comparison to modern cosmeceutical approaches including growth factor application as anti-aging ingredients. This survey has been performed for assessing the effect of herbs on proliferation, viability, and differentiation of cells.

Corrected Proof scheduled for 4 (1)

30/4/2017

Review Article

Scarless Wound Healing: Looking for a Single Remedy With Multiple Targets

Samila Farokhimanesh, Mohammad Ali Nilforoushzade, Nahid Nikkhah, Ali Komeili, Mehrak Zare

DOI: 10.5812/jssc.67299

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Context: Scars result from prolonged inflammatory phases and abnormal fibroproliferative responses in wounds. Regardless of beauty considerations that have profound psychological and social effects, scars can also have physical effects, such as growth constraints in children. Applying molecular and cellular mechanisms imitating the fetal scarless wound healing, brings about new and effective therapeutic strategies for alleviating scars. This review concentrated on innovative approaches, which simultaneously target multiple effective pathways in reducing scars.

Results: MiRNAs are unique molecular components with pleiotropic actions, which target multiple signaling pathways in scars at the same time. Fetal cells, mesenchymal stem cells, and oral mucosal cells secrete a natural relevant concentration of growth factors and cytokines that are effective in scar reduction. Fat grafting is a promising treatment for scars, providing an appropriate extra cellular matrix with homing mesenchymal stem cells.

Corrected Proof scheduled for 3 (2)

30/6/2016

Case Report

Multifocal Pyogenic Granuloma-Like Kaposi Sarcoma

Abbas Darjani, Rana Rafiei, Seyed Alireza Mesbah, Seyede Zeinab Azimi, Sara Najirad, Behnam Rafiee

DOI: 10.5812/jssc.58040

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Corrected Proof scheduled for 3 (4)

31/12/2016

Research Article

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

Shahriar Sadr Eshkevari, Nessa Aghazadeh, Roya Saedpanah, Maryam Mohammadhosseini, Sara Karimi, Nahid Nikkhah

DOI: 10.5812/jssc.66785

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Results: The results of this research demonstrated that MS was present in 41 (58.6%) LP patients vs. 12 (17.1%) controls. (OR: 6.83; P value < 0.001). All metabolic syndrome criteria were significantly common among LP patients except for decreased high density of lipoprotein level. Dyslipidemia was observed in 57 (81.42%) patients vs. 25 (31.7%) controls (OR: 7.8; P value < 0.001). No statistically significant association was found between gender, the concomitant involvement of oral mucosa, hair, or nail and MS.

Corrected Proof scheduled for 3 (2)

30/6/2016

Research Article

GO/TiO2 Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

Atieh Karbalaei, Zahra Mohammadalipour, Marveh Rahmati, Alireza Khataee, Mohammad Amin Moosavi

DOI: 10.5812/jssc.63984

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Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO₂ hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1 - 100 μg/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential for further evaluation as new generation of PSs for cancer therapy.

Uncorrected Proof scheduled for 3 (4)

31/12/2016

Case Report

New Developmental Pattern of Lesions in Alcohol - Related Adult - Type Self - Healing Cutaneous Mucinosis: A Short Report and Review of the Literatures

Najmolsadat Atefi, Elham Behrangi, Azadeh Goodarzi, Nasrin Shayanfar, Sedighe Naeji, Maryam Nokandeh, Mahba Azizi, Parvaneh Hassani, Zahra Azizian

DOI: 10.5812/jssc.67022

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Self - healing juvenile cutaneous mucinosis (SHJCM) is an extremely rare disorder that manifests by sudden onset papules and nodules in juvenile patients that primarily affects the face and peri - articular areas. There are a few reports (less than 20 cases) of Self - healing juvenile cutaneous mucinosis (SHJCM), especially self - healing adult - type cutaneous mucinosis (less than 5 cases). This report presents an alcoholic 23 - year - old male with hard nodular mucinous lesions that was progressively converted to the soft papular type. To the best of the author’s knowledge an d based on the literature, this is a new pattern of mucinous lesions in conjunction with alcohol consumption, as a new probable triggering factor. Due to the self - limiting nature of this disorder, the diagnosis should be kept in the physician’s mind to prevent unnecessary diagnostic or aggressive therapeutic approaches in acute onset cutaneous mucinous.

Corrected Proof scheduled for 3 (2)

30/6/2016

Research Article

Complications of Botulinum Toxin-A Injection in an Iranian Population

Marzieh Afrozandeh, Amir Heydariyan, Zahra Azizian

DOI: 10.5812/jssc.63334

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Methods: The present study was conducted on 235 patients referring to the dermatology clinic of Rasoul Akram hospital in Iran (including 82 men and 153 women with a mean age of 50 years) for the treatment of forehead, frown, and lateral orbital rim wrinkles between 2011 and 2015. The injection level was 35 units of botulinum toxin-A (NEURONOX) for women and 45 for men in the glabella area, and 15 units for women and 20 units for men in the crow’s feet area.

Results: The complications of botulinum toxin-A injection among 235 subjects were as follows: 1.3% ptosis (n = 3), 1.7% angioneurotic edema (n = 4), 2.1% vasovagal syncope (n = 5), 3.8% haematoma (n = 9), 1.7% diplopia (n = 4), and 2.1% musculoskeletal pain (n = 5). The satisfaction rate of patients with a complication measured one month after injection indicated that 63.3% (19/30) were satisfied with the injection and 36.7% (11/30) were dissatisfied. The satisfaction rate of patients without a complication showed that 91.7% (188/205) were pleased and 8.3% (17/205) were dissatisfied with the injection.

Uncorrected Proof scheduled for 3 (4)

20/12/2016

Research Article

A Double Blind Randomized Trial of Efficacy and Safety of 5% Methimazole Versus 2% Hydroquinone in Patients with Melasma

Najmolsadat Atefi, Elham Behrangi, Somaye Nasiripour, Golnaz Mehran, Sedighe Naeji, Mahba Azizi, Parvaneh Hassani, Zahra Azizian

DOI: 10.5812/jssc.62113

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Methods: This was a randomized, controlled, double-blind clinical trial. Fifty-eight patients aged 18 to 50, and who had been clinically diagnosed with melasma were enrolled. They were randomly divided to 2 groups: those treated with 5% methimazole cream and those treated with 2% hydroquinone once nightly for 8 weeks. Their responses to treatment were evaluated using the Melasma area and severity index (MASI), the ΔE score obtained using VisioFace digital photography, and the patients’ own satisfaction. Safety was assessed by measuring thyroid-stimulating hormone (TSH) levels. For statistical analysis, the SPSS version 16.0 for Windows (SPSS Inc., Chicago, IL) was used.

Results: The subjective assessments of methimazole and hydroquinone (patient satisfaction) were as follows: excellent and good, 67.7% for methimazole vs. 70.3% for hydroquinone, and moderate and mild, 32.2% for methimazole versus 29.6% for hydroquinone. The assessments showed no statistical differences between the 2 groups (P = 0.942). At the end of treatment, MASI scores were significantly lower in the methimazole group than in the hydroquinone group (P = 0.042). The VisioFaceΔE scores were also significantly lower in the methimazole group than in the hydroquinone group (P = 0.049). Serum thyroid stimulating hormone (TSH) levels showed no statistical differences between the 2 groups (P = 0.613).

Corrected Proof scheduled for 3 (2)

30/6/2017

Review Article

Melanoma and Associated MicroRNAs

Negin Afrang, Mehrnaz Imani, Maryam Honardoost

DOI: 10.5812/jssc.63854

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Conclusions: This review study included various investigations concerning miRNA traces as molecular rearrangements in melanoma. It was revealed that multiple miRNAs are efficient in molecular signaling and can be used as prognostic, diagnostic, and therapeutic biomarkers. Although the exact relationship between aberrant expression of miRNAs and cancers has been confirmed, further studies are required to introduce more thorough and accurate applications of miRNAs in melanoma.

Corrected Proof scheduled for 3 (4)

21/6/2016

Research Article

The Combined Effects of Nano-Zinc, Nano-Albumin and Honey in Healing Wounds Caused by Third-Degree Burn in Male Mice

Zahra Saremi, Reza Yari, Iraj Khodadadi, Seyed Mahdi Tabatabaei

DOI: 10.5812/jssc.66329

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Methods: In this experimental study, 16 adult male mice were randomly divided to experimental group 1 (treated with honey and nano-zinc), experimental group 2 (treated with nano-albumin and honey), experimental group 3 (treated with honey, nano-albumin, and nano-zinc), and group 4 (no treatment). Under sterile conditions and using general anesthesia, third-degree burns on the back of each mouse was created. Topical burn treatment was performed once a day for 6 weeks, and after the end of treatment, the mice were scarified by anesthesia and then a sample of wound bed of mice was prepared and fixed in formalin. A histological process was performed on the samples. The specimens were stained with H and E staining and microscopic observations were made.

Published by: Kowsar

Journal of Skin and Stem Cell: In Press (In Press), 10 articles.