Journal of Skin and Stem Cell

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Inflamma-miRs, Mito-miRs, and SA-miRs: Are They at the Crossroads of Inflammaging?

Samila Farokhimanesh 1 , * , Ali Komeili 2 , ** , Mohammad Ali Nilforoushzadeh 3 and Mehrak Zare 3
Authors Information
1 Department of Biotechnology, Islamic Azad University, Tehran, Iran
2 Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
Corresponding Authors:
Article information
  • Journal of Skin and Stem Cell: June 2018, 5 (1-2); e81732
  • Published Online: August 15, 2018
  • Article Type: Review Article
  • Received: July 4, 2018
  • Revised: July 24, 2018
  • Accepted: July 29, 2018
  • DOI: 10.5812/jssc.81732

To Cite: Farokhimanesh S, Komeili A, Nilforoushzadeh M A, Zare M. Inflamma-miRs, Mito-miRs, and SA-miRs: Are They at the Crossroads of Inflammaging?, J Skin Stem Cell. 2018 ; 5(1-2):e81732. doi: 10.5812/jssc.81732.

Copyright © 2018, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Franceschi C, Garagnani P, Vitale G, Capri M, Salvioli S. Inflammaging and 'Garb-aging'. Trends Endocrinol Metab. 2017;28(3):199-212. doi: 10.1016/j.tem.2016.09.005. [PubMed: 27789101].
  • 2. Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128(1):92-105. doi: 10.1016/j.mad.2006.11.016. [PubMed: 17116321].
  • 3. Flynn MG, Markofski MM, Carrillo AE. Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity? Aging Dis. 2018. doi: 10.14336/ad.2018.0326.
  • 4. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-9. doi: 10.1093/gerona/glu057. [PubMed: 24833586].
  • 5. Bandiera S, Mategot R, Girard M, Demongeot J, Henrion-Caude A. MitomiRs delineating the intracellular localization of microRNAs at mitochondria. Free Radic Biol Med. 2013;64:12-9. doi: 10.1016/j.freeradbiomed.2013.06.013. [PubMed: 23792138].
  • 6. Picca A, Lezza AMS, Leeuwenburgh C, Pesce V, Calvani R, Landi F, et al. Fueling inflamm-aging through mitochondrial dysfunction: Mechanisms and molecular targets. Int J Mol Sci. 2017;18(5). doi: 10.3390/ijms18050933. [PubMed: 28452964]. [PubMed Central: PMC5454846].
  • 7. Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 2005;8(1):3-5. doi: 10.1089/rej.2005.8.3. [PubMed: 15798367].
  • 8. Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging. Cell. 2011;146(5):682-95. doi: 10.1016/j.cell.2011.07.030. [PubMed: 21884931].
  • 9. Duarte FV, Palmeira CM, Rolo AP. The role of microRNAs in mitochondria: Small players acting wide. Genes (Basel). 2014;5(4):865-86. doi: 10.3390/genes5040865. [PubMed: 25264560]. [PubMed Central: PMC4276918].
  • 10. Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, Keith WN. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta. 2009;1792(4):341-52. doi: 10.1016/j.bbadis.2009.02.003. [PubMed: 19419692].
  • 11. Markopoulos GS, Roupakia E, Tokamani M, Vartholomatos G, Tzavaras T, Hatziapostolou M, et al. Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts. Exp Gerontol. 2017;96:110-22. doi: 10.1016/j.exger.2017.06.017. [PubMed: 28658612].
  • 12. Munk R, Panda AC, Grammatikakis I, Gorospe M, Abdelmohsen K. Senescence-associated microRNAs. Int Rev Cell Mol Biol. 2017;334:177-205. doi: 10.1016/bs.ircmb.2017.03.008. [PubMed: 28838538].
  • 13. Olivieri F, Rippo MR, Procopio AD, Fazioli F. Circulating inflamma-miRs in aging and age-related diseases. Front Genet. 2013;4:121. doi: 10.3389/fgene.2013.00121. [PubMed: 23805154]. [PubMed Central: PMC3693036].
  • 14. Rippo MR, Olivieri F, Monsurro V, Prattichizzo F, Albertini MC, Procopio AD. MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a. Exp Gerontol. 2014;56:154-63. doi: 10.1016/j.exger.2014.03.002. [PubMed: 24607549].
  • 15. Kauppila TES, Kauppila JHK, Larsson NG. Mammalian mitochondria and aging: An update. Cell Metab. 2017;25(1):57-71. doi: 10.1016/j.cmet.2016.09.017. [PubMed: 28094012].
  • 16. Chistiakov DA, Sobenin IA, Revin VV, Orekhov AN, Bobryshev YV. Mitochondrial aging and age-related dysfunction of mitochondria. Biomed Res Int. 2014;2014:238463. doi: 10.1155/2014/238463. [PubMed: 24818134]. [PubMed Central: PMC4003832].
  • 17. Vilchez D, Saez I, Dillin A. The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat Commun. 2014;5:5659. doi: 10.1038/ncomms6659. [PubMed: 25482515].
  • 18. Duarte FV, Palmeira CM, Rolo AP. The emerging role of mitomiRs in the pathophysiology of human disease. Adv Exp Med Biol. 2015;888:123-54. doi: 10.1007/978-3-319-22671-2_8. [PubMed: 26663182].
  • 19. Srinivasan H, Das S. Mitochondrial miRNA (MitomiR): a new player in cardiovascular health. Can J Physiol Pharmacol. 2015;93(10):855-61. doi: 10.1139/cjpp-2014-0500. [PubMed: 26030833].
  • 20. Li P, Jiao J, Gao G, Prabhakar BS. Control of mitochondrial activity by miRNAs. J Cell Biochem. 2012;113(4):1104-10. doi: 10.1002/jcb.24004. [PubMed: 22135235]. [PubMed Central: PMC3325319].
  • 21. Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. Pre-microRNA and mature microRNA in human mitochondria. PLoS One. 2011;6(5). e20220. doi: 10.1371/journal.pone.0020220. [PubMed: 21637849]. [PubMed Central: PMC3102686].
  • 22. Sripada L, Tomar D, Prajapati P, Singh R, Singh AK, Singh R. Systematic analysis of small RNAs associated with human mitochondria by deep sequencing: detailed analysis of mitochondrial associated miRNA. PLoS One. 2012;7(9). e44873. doi: 10.1371/journal.pone.0044873. [PubMed: 22984580]. [PubMed Central: PMC3439422].
  • 23. Mercer TR, Neph S, Dinger ME, Crawford J, Smith MA, Shearwood AM, et al. The human mitochondrial transcriptome. Cell. 2011;146(4):645-58. doi: 10.1016/j.cell.2011.06.051. [PubMed: 21854988]. [PubMed Central: PMC3160626].
  • 24. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009;1(4):402-11. doi: 10.18632/aging.100042. [PubMed: 20148189]. [PubMed Central: PMC2818025].
  • 25. Catana CS, Calin GA, Berindan-Neagoe I. Inflamma-miRs in aging and breast cancer: Are they reliable players? Front Med (Lausanne). 2015;2:85. doi: 10.3389/fmed.2015.00085. [PubMed: 26697428]. [PubMed Central: PMC4678211].
  • 26. Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Mitochondria in cell senescence: Is mitophagy the weakest link? EBioMedicine. 2017;21:7-13. doi: 10.1016/j.ebiom.2017.03.020. [PubMed: 28330601]. [PubMed Central: PMC5514379].
  • 27. Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab. 2016;23(2):303-14. doi: 10.1016/j.cmet.2015.11.011. [PubMed: 26686024]. [PubMed Central: PMC4749409].
  • 28. Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, et al. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35(7):724-42. doi: 10.15252/embj.201592862. [PubMed: 26848154]. [PubMed Central: PMC4818766].
  • 29. Correia-Melo C, Passos JF. Mitochondria: Are they causal players in cellular senescence? Biochim Biophys Acta. 2015;1847(11):1373-9. doi: 10.1016/j.bbabio.2015.05.017. [PubMed: 26028303].

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