Journal of Skin and Stem Cell

Published by: Kowsar

Comparing Efficacy and Tolerability of Triamcinolone and Verapamil in Treatment of Hypertrophic Scars and Keloids

Abbas Zamanian 1 , Maryam Nokandeh 1 , * , Elham Behrangi 1 , Zeynab Fazel 1 and Zahra Azizian 1
Authors Information
1 Rasoul - e - akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: September 2017, 4 (3); e69390
  • Published Online: September 30, 2017
  • Article Type: Research Article
  • Received: July 10, 2017
  • Revised: August 15, 2017
  • Accepted: September 1, 2017
  • DOI: 10.5812/jssc.69390

To Cite: Zamanian A, Nokandeh M, Behrangi E, Fazel Z, Azizian Z. et al. Comparing Efficacy and Tolerability of Triamcinolone and Verapamil in Treatment of Hypertrophic Scars and Keloids, J Skin Stem Cell. 2017 ;4(3):e69390. doi: 10.5812/jssc.69390.

Abstract
Copyright © 2017, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
References
  • 1. Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr. 2006;18(4):396-402. doi: 10.1097/01.mop.0000236389.41462.ef. [PubMed: 16914994].
  • 2. Wheeland RG. Keloids and hypertrphic scars. In: Arndt KA, Robinson JK, Leboit PE, Wintroub BU, editors. Cutaneous Medicine and Surgery. Philadelphia: Saunders Elsevier; 1996. p. 900-5.
  • 3. Murray JC. Keloids and hypertrophic scars. Clin Dermatol. 1994;12(1):27-37.
  • 4. Muir IF. On the nature of keloid and hypertrophic scars. Br J Plast Surg. 1990;43(1):61-9. [PubMed: 2310898].
  • 5. Niessen FB, Spauwen PHM, Schalkwijk J, Kon M. On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg. 1999;104(5):1435-58.
  • 6. Sephel GC, Woodward SC. Repair, regeneration, and fibrosis. In: Rubin E, editor. Rubin's Pathology. Baltimore: Lippincott, Williams & Wilkins; 2001. p. 84-117.
  • 7. Deitch EA, Wheelahan TM, Rose MP, Clothier J, Cotter J. Hypertrophic Burn Scars. J Trauma Inj Infect Crit Care. 1983;23(10):895-8. doi: 10.1097/00005373-198310000-00009.
  • 8. Lewis WHP, Sun KKY. Hypertrophic scar: a genetic hypothesis. Burns. 1990;16(3):176-8. doi: 10.1016/0305-4179(90)90033-s.
  • 9. Murray CJ, Pinnel SR. Keloids and excessive dermal scarring. In: Cohen IK, Diegelmann RF, Lindblad WJ, editors. Woundhealing, Biochemical and Clinical Aspects. Philadelphia: Saunders Elsevier; 1992. p. 500-9.
  • 10. Bayat A, Arscott G, Ollier WER, Mc Grouther DA, Ferguson MWJ. Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg. 2005;58(1):28-37. doi: 10.1016/j.bjps.2004.04.024.
  • 11. Placik OJ, Lewis VJ. Immunologic associations of keloids. Surg Gynecol Obstet. 1992;175(2):185-93. [PubMed: 1636146].
  • 12. Smith CJ, Smith JC, Finn MC. The Possible Role of Mast Cells (Allergy) in the Production of Keloid and Hypertrophic Scarring. J Burn Care Rehabil. 1987;8(2):126-31. doi: 10.1097/00004630-198703000-00008.
  • 13. Golladay ES. Treatment of keloids by single intraoperative perilesional injection of repository steroid. South Med J. 1988;81(6):736-8. [PubMed: 3287640].
  • 14. Goslen JB. The role of steroids in preventing scar formation. In: Thomas JR, Holt GR, editors. Facial Scars: Incisions, Revisions, and Camouflage. St. Louis: CV Mosby; 1989. p. 83-97.
  • 15. Atiyeh BS. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthetic Plast Surg. 2007;31(5):468-92. discussion 493-4. doi: 10.1007/s00266-006-0253-y. [PubMed: 17576505].
  • 16. Trisliana Perdanasari A, Torresetti M, Grassetti L, Nicoli F, Zhang YX, Dashti T, et al. Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes. Burns Trauma. 2015;3:14. doi: 10.1186/s41038-015-0015-7. [PubMed: 27574660]. [PubMed Central: PMC4964100].
  • 17. Ahuja RB, Chatterjee P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns. 2014;40(4):583-8. doi: 10.1016/j.burns.2013.09.029. [PubMed: 24182692].
  • 18. Margaret Shanthi FX, Ernest K, Dhanraj P. Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids. Indian J Dermatol Venereol Leprol. 2008;74(4):343-8. [PubMed: 18797054].
  • 19. Lee RC, Doong H, Jellema AF. The response of burn scars to intralesional verapamil. Report of five cases. Arch Surg. 1994;129(1):107-11. [PubMed: 8279934].
  • 20. Boggio RF, Boggio LF, Galvao BL, Machado-Santelli GM. Topical verapamil as a scar modulator. Aesthetic Plast Surg. 2014;38(5):968-75. doi: 10.1007/s00266-014-0400-9. [PubMed: 25189298].
  • 21. Yang JY, Huang CY. The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model: a new strategy for the treatment of hypertrophic scars. Dermatol Surg. 2010;36(12):1942-9. doi: 10.1111/j.1524-4725.2010.01759.x. [PubMed: 20973868].
  • 22. Meymandi SS, Moosazadeh M, Rezazadeh A. Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial. Osong Public Health Res Perspect. 2016;7(5):313-9. doi: 10.1016/j.phrp.2016.08.005. [PubMed: 27812490]. [PubMed Central: PMC5079190].
  • 23. Ren Y, Zhou X, Wei Z, Lin W, Fan B, Feng S. Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. Int Wound J. 2017;14(3):480-7. doi: 10.1111/iwj.12629. [PubMed: 27427423].
  • 24. Yu S, Li H. Microplasma radiofrequency technology combined with triamcinolone improved the therapeutic effect on Chinese patients with hypertrophic scar and reduced the risk of tissue atrophy. Ther Clin Risk Manag. 2016;12:743-7. doi: 10.2147/TCRM.S104109. [PubMed: 27274259]. [PubMed Central: PMC4869595].
  • 25. Li Z, Jin Z. Comparative effect and safety of verapamil in keloid and hypertrophic scar treatment: a meta-analysis. Ther Clin Risk Manag. 2016;12:1635-41. doi: 10.2147/TCRM.S118748. [PubMed: 27877046]. [PubMed Central: PMC5108599].
  • 26. Wang R, Mao Y, Zhang Z, Li Z, Chen J, Cen Y. Role of verapamil in preventing and treating hypertrophic scars and keloids. Int Wound J. 2016;13(4):461-8. doi: 10.1111/iwj.12455. [PubMed: 25968157].
  • 27. Rha EY, Kim YH, Kim TJ, Yoo G, Rhie JW, Kim HJ, et al. Topical Application of a Silicone Gel Sheet with Verapamil Microparticles in a Rabbit Model of Hypertrophic Scar. Plast Reconstr Surg. 2016;137(1):144-51. doi: 10.1097/PRS.0000000000001889. [PubMed: 26710018].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments