Journal of Skin and Stem Cell

Published by: Kowsar

Psoralen and UltraViolet A in Atopic Dermatitis

Shahab Abtahi 1 , Hasan Seirafi 2 , Kamran Balighi 2 , Amir Hooshang Ehsani 2 , Farshad Farnaghi 2 and Pezhman Mobasher 3 , *
Authors Information
1 Clinical Pharmacy & Toxicology Department, Academisch Ziekenhuis Maastricht, Maastricht, The Netherlands
2 Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: June 2017, 4 (2); e69286
  • Published Online: June 20, 2017
  • Article Type: Research Article
  • Received: April 22, 2017
  • Revised: May 19, 2017
  • Accepted: June 15, 2017
  • DOI: 10.5812/jssc.69286

To Cite: Abtahi S, Seirafi H, Balighi K, Ehsani A H, Farnaghi F, et al. Psoralen and UltraViolet A in Atopic Dermatitis, J Skin Stem Cell. 2017 ; 4(2):e69286. doi: 10.5812/jssc.69286.

Copyright © 2017, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Patients and Methods
3. Results
4. Discussion
  • 1. Braback L, Hjern A, Rasmussen F. Trends in asthma, allergic rhinitis and eczema among Swedish conscripts from farming and non-farming environments. A nationwide study over three decades. Clin Exp Allergy. 2004;34(1):38-43. [PubMed: 14720260].
  • 2. Galassi C, De Sario M, Biggeri A, Bisanti L, Chellini E, Ciccone G, et al. Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994-2002. Pediatrics. 2006;117(1):34-42. doi: 10.1542/peds.2004-2709. [PubMed: 16396858].
  • 3. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 2000;105(5):860-76. doi: 10.1067/mai.2000.106484. [PubMed: 10808164].
  • 4. Chan LS. Atopic dermatitis in 2008. Dermatologic Immunity. Karger Publishers; 2008.
  • 5. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129(8):1892-908. doi: 10.1038/jid.2009.133. [PubMed: 19494826].
  • 6. Novak N. New insights into the mechanism and management of allergic diseases: atopic dermatitis. Allergy. 2009;64(2):265-75. doi: 10.1111/j.1398-9995.2008.01922.x. [PubMed: 19178406].
  • 7. Scheinfeld NS, Tutrone WD, Weinberg JM, DeLeo VA. Phototherapy of atopic dermatitis. Clin Dermatol. 2003;21(3):241-8. doi: 10.1016/s0738-081x(02)00364-4.
  • 8. Morita A. Newly Developed Phototherapy for Atopic Dermatitis. Allergology International. 2005;54(2):175-80. doi: 10.2332/allergolint.54.175.
  • 9. Krutmann J, Honigsmann H, Elmets CA, Bergstresser PR. Dermatological Phototherapy and Photodiagnostic Methods. Berlin Heidelberg GmbH: Springer-Verlag; 2001.
  • 10. Fluhr JW, Gloor M. The antimicrobial effect of narrow-band UVB (313 nm) and UVA1 (345-440 nm) radiation in vitro. Photodermatol Photoimmunol Photomed. 1997;13(5-6):197-201. [PubMed: 9542758].
  • 11. Morison WL, Parrish J, Fitzpatrick TB. Oral psoralen photochemotherapy of atopic eczema. Br J Dermatol. 1978;98(1):25-30. [PubMed: 626712].
  • 12. Majoie IM, Oldhoff JM, van Weelden H, Laaper-Ertmann M, Bousema MT, Sigurdsson V, et al. Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis. J Am Acad Dermatol. 2009;60(1):77-84. doi: 10.1016/j.jaad.2008.08.048. [PubMed: 19103360].
  • 13. Meduri NB, Vandergriff T, Rasmussen H, Jacobe H. Phototherapy in the management of atopic dermatitis: a systematic review. Photodermatol Photoimmunol Photomed. 2007;23(4):106-12. doi: 10.1111/j.1600-0781.2007.00291.x. [PubMed: 17598862].
  • 14. Rai R, Srinivas CR. Phototherapy: an Indian perceptive. Indian J Dermatol. 2007;52(4):169.
  • 15. Sheehan MP, Atherton DJ, Norris P, Hawk J. Oral psoralen photochemotherapy in severe childhood atopic eczema: an update. Br J Dermatol. 1993;129(4):431-6. [PubMed: 8217758].
  • 16. Tzaneva S, Kittler H, Holzer G, Reljic D, Weber M, Honigsmann H, et al. 5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomized crossover trial. Br J Dermatol. 2010;162(3):655-60. doi: 10.1111/j.1365-2133.2009.09514.x. [PubMed: 19769631].
  • 17. Nabi H, Shams-ud-Din S, Asad F, Nadeem M. Efficacy and safety of narrowband ultraviolet B therapy in moderate to severe atopic dermatitis. J Pakistan Assoc Dermatol. 2016;21(2):106-8.
  • 18. Hanifin JM. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Suppl). 1980;92:44-7.
  • 19. Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1997;195(1):10-9. doi: 10.1159/000245677. [PubMed: 9267730].
  • 20. Nantes , Bordeaux . Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis,. Dermatology. 1993;186(1):23-31. doi: 10.1159/000247298. [PubMed: 8435513].
  • 21. de Kort WJ, van Weelden H. Bath psoralen-ultraviolet A therapy in atopic eczema. J Eur Acad Dermatol Venereol. 2000;14(3):172-4. [PubMed: 11032059].
  • 22. Der-Petrossian M, Seeber A, Honigsmann H, Tanew A. Half-side comparison study on the efficacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis. Br J Dermatol. 2000;142(1):39-43. [PubMed: 10651692].

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