Journal of Skin and Stem Cell

Published by: Kowsar

A Substrate for Stem Cell Culture and Differentiation

Neda Keyhanvar 1 , 2 , 3 , * , Rana Amanpour 2 , 3 and Mohammad Nouri 1 , 2
Authors Information
1 Medical Biotechnology Department, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Journal of Skin and Stem Cell: September 2016, 3 (3); e64047
  • Published Online: June 21, 2016
  • Article Type: Research Article
  • Received: April 12, 2016
  • Revised: May 5, 2016
  • Accepted: June 6, 2016
  • DOI: 10.5812/jssc.64047

To Cite: Keyhanvar N, Amanpour R, Nouri M. A Substrate for Stem Cell Culture and Differentiation, J Skin Stem Cell. 2016 ; 3(3):e64047. doi: 10.5812/jssc.64047.

Copyright © 2016, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Introduction
2. Methods
3. Results
4. Discussion and Conclusion
  • 1. Zhong SP, Zhang YZ, Lim CT. Tissue scaffolds for skin wound healing and dermal reconstruction. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(5):510-25. doi: 10.1002/wnan.100. [PubMed: 20607703].
  • 2. Wong VW, Levi B, Rajadas J, Longaker MT, Gurtner GC. Stem cell niches for skin regeneration. Int J Biomater. 2012;2012:926059. doi: 10.1155/2012/926059. [PubMed: 22701121].
  • 3. Cerqueira MT, Marques AP, Reis RL. Using stem cells in skin regeneration: possibilities and reality. Stem Cells Dev. 2012;21(8):1201-14. doi: 10.1089/scd.2011.0539. [PubMed: 22188597].
  • 4. Weger M, Diotel N, Dorsemans AC, Dickmeis T, Weger BD. Stem cells and the circadian clock. Dev Biol. 2017;431(2):111-23. doi: 10.1016/j.ydbio.2017.09.012. [PubMed: 28899666].
  • 5. Ogliari KS, Marinowic D, Brum DE, Loth F. Stem cells in dermatology. An Bras Dermatol. 2014;89(2):286-91. [PubMed: 24770506].
  • 6. Bindu A H, B S. Potency of Various Types of Stem Cells and their Transplantation. J Stem Cell Res Ther. 2011;1(3). doi: 10.4172/2157-7633.1000115.
  • 7. Fuchs E. Skin stem cells: rising to the surface. J Cell Biol. 2008;180(2):273-84. doi: 10.1083/jcb.200708185. [PubMed: 18209104].
  • 8. Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 2009;5(1):17-26. doi: 10.1016/j.stem.2009.06.016. [PubMed: 19570510].
  • 9. Niknejad H, Mirmasoumi M, Torabi B, Deheshkar-Farahani N. Near-IR absorbing quantum dots might be usable for growth factor-based differentiation of stem cells. J Med Hypotheses Ideas. 2015;9(1):24-8. doi: 10.1016/j.jmhi.2015.01.003.
  • 10. Seunarine K, Meredith DO, Riehle MO, Wilkinson CDW, Gadegaard N. Biodegradable polymer tubes with lithographically controlled 3D micro- and nanotopography. Microelectron Engin. 2008;85(5-6):1350-4. doi: 10.1016/j.mee.2008.02.002.
  • 11. Mahmoudi M, Bonakdar S, Shokrgozar MA, Aghaverdi H, Hartmann R, Pick A, et al. Cell-imprinted substrates direct the fate of stem cells. ACS Nano. 2013;7(10):8379-84. doi: 10.1021/nn403844q. [PubMed: 24059979].
  • 12. Lucker PB, Javaherian S, Soleas JP, Halverson D, Zandstra PW, McGuigan AP. A microgroove patterned multiwell cell culture plate for high-throughput studies of cell alignment. Biotechnol Bioeng. 2014;111(12):2537-48. doi: 10.1002/bit.25298. [PubMed: 24889796].
  • 13. Parikh KS, Rao SS, Ansari HM, Zimmerman LB, Lee LJ, Akbar SA, et al. Ceramic nanopatterned surfaces to explore the effects of nanotopography on cell attachment. Materials Sci Engin C. 2012;32(8):2469-75. doi: 10.1016/j.msec.2012.07.028.
  • 14. Zouani OF, Chanseau C, Brouillaud B, Bareille R, Deliane F, Foulc MP, et al. Altered nanofeature size dictates stem cell differentiation. J Cell Sci. 2012;125(Pt 5):1217-24. doi: 10.1242/jcs.093229. [PubMed: 22302989].
  • 15. Kim J, Kim HN, Lim KT, Kim Y, Seonwoo H, Park SH, et al. Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells. Sci Rep. 2013;3:3552. doi: 10.1038/srep03552. [PubMed: 24352057].
  • 16. Cyster LA, Parker KG, Parker TL, Grant DM. The effect of surface chemistry and nanotopography of titanium nitride (TiN) films on 3T3-L1 fibroblasts. J Biomed Mater Res A. 2003;67(1):138-47. doi: 10.1002/jbm.a.10087. [PubMed: 14517871].
  • 17. Kim HN, Hong Y, Kim MS, Kim SM, Suh KY. Effect of orientation and density of nanotopography in dermal wound healing. Biomaterials. 2012;33(34):8782-92. doi: 10.1016/j.biomaterials.2012.08.038. [PubMed: 22959181].
  • 18. Teo BK, Goh KJ, Ng ZJ, Koo S, Yim EK. Functional reconstruction of corneal endothelium using nanotopography for tissue-engineering applications. Acta Biomater. 2012;8(8):2941-52. doi: 10.1016/j.actbio.2012.04.020. [PubMed: 22522131].
  • 19. Yang M, Yang N, Bi S, He X, Chen L, Zhu Z, et al. Micropatterned designs of thermoresponsive surfaces for modulating cell behaviors. Polymers Adv Technol. 2013;24(12):1102-9. doi: 10.1002/pat.3196.
  • 20. McNamara LE, McMurray RJ, Biggs MJ, Kantawong F, Oreffo RO, Dalby MJ. Nanotopographical control of stem cell differentiation. J Tissue Eng. 2010;2010:120623. doi: 10.4061/2010/120623. [PubMed: 21350640].
  • 21. Choi CH, Hagvall SH, Wu BM, Dunn JC, Beygui RE, C. J. Kim CJ . Cell interaction with three-dimensional sharp-tip nanotopography. Biomaterials. 2007;28(9):1672-9. doi: 10.1016/j.biomaterials.2006.11.031. [PubMed: 17174392].
  • 22. Driscoll MK, Sun X, Guven C, Fourkas JT, Losert W. Cellular contact guidance through dynamic sensing of nanotopography. ACS Nano. 2014;8(4):3546-55. doi: 10.1021/nn406637c. [PubMed: 24649900].
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