Journal of Skin and Stem Cell

Published by: Kowsar

Different Concentrations of Titanium Dioxide Nanoparticles Induce Autophagy Followed by Growth Inhibition or Cell Death in A375 Melanoma Cells

Zahra Mohammadalipour 1 , Marveh Rahmati 2 , Alireza Khataee 3 and Mohammad Amin Moosavi 1 , *
Authors Information
1 Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
2 Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
Article information
  • Journal of Skin and Stem Cell: June 2017, 4 (2); e63994
  • Published Online: June 30, 2017
  • Article Type: Research Article
  • Received: April 20, 2017
  • Revised: May 23, 2017
  • Accepted: June 19, 2017
  • DOI: 10.5812/jssc.63994

To Cite: Mohammadalipour Z, Rahmati M, Khataee A, Moosavi M A. Different Concentrations of Titanium Dioxide Nanoparticles Induce Autophagy Followed by Growth Inhibition or Cell Death in A375 Melanoma Cells, J Skin Stem Cell. 2017 ;4(2):e63994. doi: 10.5812/jssc.63994.

Abstract
Copyright © 2017, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnote
References
  • 1. Garbe C, Eigentler TK, Keilholz U, Hauschild A, Kirkwood JM. Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist. 2011;16(1):5-24. doi: 10.1634/theoncologist.2010-0190. [PubMed: 21212434]. [PubMed Central: PMC3228046].
  • 2. Berciano-Guerrero MA, Montesa-Pino A, Castaneda-Penalvo G, Munoz-Fernandez L, Rodriguez-Flores J. Nanoparticles in melanoma. Curr Med Chem. 2014;21(32):3701-16. [PubMed: 25039783].
  • 3. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651-62. doi: 10.1056/NEJMra1205406. [PubMed: 23406030].
  • 4. Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett. 2010;584(7):1427-35. doi: 10.1016/j.febslet.2009.12.034. [PubMed: 20035753]. [PubMed Central: PMC2843775].
  • 5. Mokarram P, Albokashy M, Zarghooni M, Moosavi MA, Sepehri Z, Chen QM, et al. New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy. 2017;13(5):781-819. doi: 10.1080/15548627.2017.1290751. [PubMed: 28358273]. [PubMed Central: PMC5446063].
  • 6. Salata O. Applications of nanoparticles in biology and medicine. J Nanobiotechnology. 2004;2(1):3. doi: 10.1186/1477-3155-2-3. [PubMed: 15119954]. [PubMed Central: PMC419715].
  • 7. Lopes VR, Loitto V, Audinot JN, Bayat N, Gutleb AC, Cristobal S. Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels. J Nanobiotechnology. 2016;14:22. doi: 10.1186/s12951-016-0174-0. [PubMed: 27001369]. [PubMed Central: PMC4802894].
  • 8. Rezaei B, Mosaddeghi H, editors. Applications of Titanium Dioxide Nanocoating. Nano-Technology in Environments Conference. 2006.
  • 9. Zhang H, Shan Y, Dong L. A comparison of TiO2 and ZnO nanoparticles as photosensitizers in photodynamic therapy for cancer. J Biomed Nanotechnol. 2014;10(8):1450-7. [PubMed: 25016645].
  • 10. Zhu Y, Eaton JW, Li C. Titanium dioxide (TiO2) nanoparticles preferentially induce cell death in transformed cells in a Bak/Bax-independent fashion. PLoS One. 2012;7(11). e50607. doi: 10.1371/journal.pone.0050607. [PubMed: 23185639]. [PubMed Central: PMC3503962].
  • 11. Chen HW, Su SF, Chien CT, Lin WH, Yu SL, Chou CC, et al. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. FASEB J. 2006;20(13):2393-5. doi: 10.1096/fj.06-6485fje. [PubMed: 17023518].
  • 12. Pujalte I, Dieme D, Haddad S, Serventi AM, Bouchard M. Toxicokinetics of titanium dioxide (TiO2) nanoparticles after inhalation in rats. Toxicol Lett. 2017;265:77-85. doi: 10.1016/j.toxlet.2016.11.014. [PubMed: 27884615].
  • 13. Sun Q, Ishii T, Kanehira K, Sato T, Taniguchi A. Uniform TiO2 nanoparticles induce apoptosis in epithelial cell lines in a size-dependent manner. Biomater Sci. 2017;5(5):1014-21. doi: 10.1039/c6bm00946h. [PubMed: 28338134].
  • 14. Moosavi MA, Sharifi M, Ghafary SM, Mohammadalipour Z, Khataee A, Rahmati M, et al. Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells. Sci Rep. 2016;6:34413. doi: 10.1038/srep34413. [PubMed: 27698385]. [PubMed Central: PMC5048164].
  • 15. Zhang X, Yin H, Li Z, Zhang T, Yang Z. Nano-TiO2 induces autophagy to protect against cell death through antioxidative mechanism in podocytes. Cell Biol Toxicol. 2016;32(6):513-27. doi: 10.1007/s10565-016-9352-y. [PubMed: 27430495].
  • 16. Yu KN, Chang SH, Park SJ, Lim J, Lee J, Yoon TJ, et al. Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. PLoS One. 2015;10(6). e0131208. doi: 10.1371/journal.pone.0131208. [PubMed: 26121477]. [PubMed Central: PMC4485469].
  • 17. Ahmadi AH, Moosavi MA, Hosseinpour Feizi MA. [The inductive effect of boric acid on growth inhibition and differentiating changes of human chronic myeloid leukemia K562 cell line]. Arak Med Univ J. 2010;13(3):1-11. Persian.
  • 18. Fakhimahmadi A, Nazmi F, Rahmati M, Bonab NM, Hashemi M, Moosavi MA. Nucleostemin silencing induces differentiation and potentiates all-trans-retinoic acid effects in human acute promyelocytic leukemia NB4 cells via autophagy. Leuk Res. 2017;63:15-21. doi: 10.1016/j.leukres.2017.10.007. [PubMed: 29096331].
  • 19. Rigel DS, Carucci JA. Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin. 2000;50(4):215-36. quiz 237-40. [PubMed: 10986965].
  • 20. Moan JE, Baturaite Z, Dahlback A, Porojnicu AC. Ultraviolet radiation and cutaneous malignant melanoma. Adv Exp Med Biol. 2014;810:359-74. [PubMed: 25207376].
  • 21. Cadman C. Titanium Dioxide Nanoparticles for Photodynamic Therapy. University of Manchester; 2013.
  • 22. Xu P, Wang R, Ouyang J, Chen B. A new strategy for TiO2 whiskers mediated multi-mode cancer treatment. Nanoscale Res Lett. 2015;10:94. doi: 10.1186/s11671-015-0796-4. [PubMed: 25852390]. [PubMed Central: PMC4385221].
  • 23. Khalili Fard J, Jafari S, Eghbal MA. A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles. Adv Pharm Bull. 2015;5(4):447-54. doi: 10.15171/apb.2015.061. [PubMed: 26819915]. [PubMed Central: PMC4729339].
  • 24. Sohaebuddin SK. Mechanism of nanoparticle and nanotube-induced cell death. The University of Texas at Arlington; 2008.
  • 25. Thevenot PT. Functionalized nanoparticles for the selective killing of cancer cells. The University of Texas at Arlington; 2007.
  • 26. Seo JW, Chung H, Kim MY, Lee J, Choi IH, Cheon J. Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment. Small. 2007;3(5):850-3. doi: 10.1002/smll.200600488. [PubMed: 17385208].
  • 27. Lagopati N, Kitsiou PV, Kontos AI, Venieratos P, Kotsopoulou E, Kontos AG, et al. Photo-induced treatment of breast epithelial cancer cells using nanostructured titanium dioxide solution. J Photochem Photobiol Chem. 2010;214(2-3):215-23. doi: 10.1016/j.jphotochem.2010.06.031.
  • 28. Li Z, Pan X, Wang T, Wang PN, Chen JY, Mi L. Comparison of the killing effects between nitrogen-doped and pure TiO2 on HeLa cells with visible light irradiation. Nanoscale Res Lett. 2013;8(1):96. doi: 10.1186/1556-276X-8-96. [PubMed: 23433090]. [PubMed Central: PMC3599500].
  • 29. Lotfian H, Nemati F. Cytotoxic effect of tio2 nanoparticles on breast cancer cell line (MCF-7). IIOAB J. 2016;7:219-24.
  • 30. Cheng Y, Ren X, Hait WN, Yang JM. Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev. 2013;65(4):1162-97. doi: 10.1124/pr.112.007120. [PubMed: 23943849]. [PubMed Central: PMC3799234].
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