Journal of Skin and Stem Cell

Published by: Kowsar

Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo

Elham Behrangi 1 , Abbas Rasi 1 , Faezeh Jannati 2 , * , Parvin Jannati 2 , Farzaneh Beigmohammadi 3 and Zahra Azizian 1
Authors Information
1 Dermatology Department, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2 Dermatologist, Tehran, Iran
3 Iran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: June 1, 2015, 2 (2); e30410
  • Published Online: June 23, 2015
  • Article Type: Research Article
  • Received: May 31, 2015
  • Accepted: June 3, 2015
  • DOI: 10.17795/jssc30410

To Cite: Behrangi E, Rasi A, Jannati F, Jannati P, Beigmohammadi F, et al. Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo, J Skin Stem Cell. 2015 ; 2(2):e30410. doi: 10.17795/jssc30410.

Copyright © 2015, Skin and Stem Cell Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Goldfarb MT, Ellis CN, Voorhees JJ. Topical tretinoin: its use in daily practice to reverse photoageing. Br J Dermatol. 1990; 122 Suppl 35: 87-91[PubMed]
  • 2. Gilchrest BA. Retinoids and photodamage. Br J Dermatol. 1992; 127 Suppl 41: 14-20[PubMed]
  • 3. Koster W, Wiskemann A. [Phototherapy with UV-B in vitiligo]. Z Hautkr. 1990; 65(11): 1022-4[PubMed]
  • 4. Xu AE, Zhang DM, Wei XD, Huang B, Lu LJ. Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo. Int J Dermatol. 2009; 48(1): 86-90[DOI][PubMed]
  • 5. Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993; 329(8): 530-5[DOI][PubMed]
  • 6. Kwon HB, Choi Y, Kim HJ, Lee AY. The therapeutic effects of a topical tretinoin and corticosteroid combination for vitiligo: a placebo-controlled, paired-comparison, left-right study. J Drugs Dermatol. 2013; 12(4)-7[PubMed]
  • 7. Lesnik RH, Mezick JA, Capetola R, Kligman LH. Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. J Am Acad Dermatol. 1989; 21(2 Pt 1): 186-90[PubMed]
  • 8. De Lacharriere O, Escoffier C, Gracia AM, Teillac D, Saint Leger D, Berrebi C, et al. Reversal effects of topical retinoic acid on the skin of kidney transplant recipients under systemic corticotherapy. J Invest Dermatol. 1990; 95(5): 516-22[PubMed]
  • 9. Kligman LH, Schwartz E, Lesnik RH, Mezick JA. Topical tretinoin prevents corticosteroid-induced atrophy without lessening the anti-inflammatory effect. Curr Probl Dermatol. 1993; 21: 79-88[PubMed]
  • 10. Yoshimura K, Tsukamoto K, Okazaki M, Virador VM, Lei TC, Suzuki Y, et al. Effects of all-trans retinoic acid on melanogenesis in pigmented skin equivalents and monolayer culture of melanocytes. J Dermatol Sci. 2001; 27 Suppl 1-75[PubMed]
  • 11. Parsad D, Saini R, Juneja A. Combination of clobetasol and tretinoin in vitiligo -letter. Int J Dermatol. 2000; 39(8): 639-40[PubMed]
  • 12. Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, et al. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol. 2008; 181(4): 2277-84[PubMed]
  • 13. Ma J, Liu Y, Li Y, Gu J, Liu J, Tang J, et al. Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells. J Leukoc Biol. 2014; 95(2): 275-83[DOI][PubMed]
  • 14. Kinoshita K, Yoo BS, Nozaki Y, Sugiyama M, Ikoma S, Ohno M, et al. Retinoic acid reduces autoimmune renal injury and increases survival in NZB/W F1 mice. J Immunol. 2003; 170(11): 5793-8[PubMed]
  • 15. Bellemere G, Von Stetten O, Oddos T. Retinoic acid increases aquaporin 3 expression in normal human skin. J Invest Dermatol. 2008; 128(3): 542-8[DOI][PubMed]
  • 16. Cao C, Wan S, Jiang Q, Amaral A, Lu S, Hu G, et al. All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J Cell Physiol. 2008; 215(2): 506-16[DOI][PubMed]
  • 17. Hguyen QH, Kim YA, Schwartz RA. Management of acne vulgaris . Am Fam Physician. 1994; 50(1): 89
  • 18. Kubbak R, Bajaj AK, Thappa DM. Topical Retinoids. Indian J Dermatol Venerol Leprol. 2009; 75: 28-30
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments