Journal of Skin and Stem Cell

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Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts

Mohammad Ali Nilforoushzadeh 1 , Fariba Jaffary 1 , 2 , * , Mansour Siavash 3 , Asieh Heidari 2 , Nazli Ansari 2 and Amir Hossein Siadat 4
Authors Information
1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
Article information
  • Journal of Skin and Stem Cell: October 1, 2014, 1 (2); e23312
  • Published Online: October 18, 2014
  • Article Type: Case Report
  • Received: September 6, 2014
  • Accepted: September 9, 2014
  • DOI: 10.17795/jssc23312

To Cite: Nilforoushzadeh M A, Jaffary F, Siavash M, Heidari A, Ansari N, et al. Treatment of Recalcitrant Diabetic Ulcers With Trichloroacetic Acid and Fibroblasts, J Skin Stem Cell. 2014 ; 1(2):e23312. doi: 10.17795/jssc23312.

Copyright © 2014, Skin and Stem Cell Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Instruction
2. Case Presentation
3. Discussion
  • 1. Dalla Paola L, Faglia E. Treatment of diabetic foot ulcer: an overview strategies for clinical approach. Curr Diabetes Rev. 2006; 2(4): 431-47[PubMed]
  • 2. Aalami HB, Aalami HA, Siavashi B. Diabetic Foot Ulcer Management Review of Literature. Iran J Surgery . 2009; 16(4): 1-7
  • 3. Hinchliffe RJ, Valk GD, Apelqvist J, Armstrong DG, Bakker K, Game FL, et al. A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2008; 24 Suppl 1-44[DOI][PubMed]
  • 4. Nilforoushzadeh MA, Jaffary F, Ansari N, Siadat AH, Heidari A, Adibi N. Treatment of recalcitrant diabetic ulcers using trichloroacetic acid: A case series of 6 patients. J Res Med Sci. 2012; 17(5)-91
  • 5. Lavery LA, Armstrong DG, Harkless LB. Classification of diabetic foot wounds. The Journal of Foot and Ankle Surgery. 1996; 35(6): 528-31[DOI]
  • 6. Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986; 204(3): 322-30[PubMed]
  • 7. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005; 293(2): 217-28[DOI][PubMed]
  • 8. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. Healing diabetic neuropathic foot ulcers: are we getting better? Diabet Med. 2005; 22(2): 172-6[DOI][PubMed]
  • 9. Nguyen TH, Rooney JA. Trichloroacetic acid peels. Dermatol Ther. 2000; 13(2): 173-82[DOI]
  • 10. Nifroushzadeh MA, Jaffary F, Reiszadeh MR. Comparative Effect of Topical Trichloroacetic Acid and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis. Int J Pharmacol. 2006; 2(6): 633-6[DOI]
  • 11. Ulicna M, Danisovic L, Vojtassak J. Does cell therapy and tissue engineering represent a promising treatment of diabetic foot ulcers. Bratisl Lek Listy. 2010; 111(3): 138-43
  • 12. Marston WA, Hanft J, Norwood P, Pollak R, Dermagraft Diabetic Foot Ulcer Study G. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care. 2003; 26(6): 1701-5[PubMed]
  • 13. Wong T, McGrath JA, Navsaria H. The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol. 2007; 156(6): 1149-55[DOI][PubMed]
  • 14. Gibbs S, van den Hoogenband HM, Kirtschig G, Richters CD, Spiekstra SW, Breetveld M, et al. Autologous full-thickness skin substitute for healing chronic wounds. Br J Dermatol. 2006; 155(2): 267-74[DOI][PubMed]
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