Journal of Skin and Stem Cell

Published by: Kowsar

Association of Mycosis Fungoides and Large Plaque Parapsoriasis with Human Herpes Virus 8

Hamideh Moravvej 1 , Saeed Aref 2 , Hossein Keyvani 3 , Ehsan Abolhasani 1 , Nima Sarrafi Rad 1 and Reza Jafari|Fesharaki 1 , *
Authors Information
1 Skin Research center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Tehran University of Medical Science, Tehran, Iran
3 Department of Virology, Tehran University of Medical Science, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: October 1, 2014, 1 (2); e21562
  • Published Online: October 1, 2014
  • Article Type: Research Article
  • Received: March 20, 2014
  • Revised: April 10, 2014
  • Accepted: April 30, 2014
  • DOI: 10.17795/jssc21562

To Cite: Moravvej H, Aref S, Keyvani H, Abolhasani E, Sarrafi Rad N, et al. Association of Mycosis Fungoides and Large Plaque Parapsoriasis with Human Herpes Virus 8, J Skin Stem Cell. 2014 ; 1(2):e21562. doi: 10.17795/jssc21562.

Copyright © 2014, Skin and Stem Cell Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Willemze R, Meijer CJ. Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC. J Cutan Pathol. 2006; 33 Suppl 1: 18-26[DOI][PubMed]
  • 2. Lambert WC, Everett MA. The nosology of parapsoriasis. J Am Acad Dermatol. 1981; 5(4): 373-95[PubMed]
  • 3. Burg G, Dummer R, Nestle FO, Doebbeling U, Haeffner A. Cutaneous lymphomas consist of a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis. Arch Dermatol. 1996; 132(5): 567-72[PubMed]
  • 4. Tan RS, Butterworth CM, McLaughlin H, Malka S, Samman PD. Mycosis fungoides--a disease of antigen persistence. Br J Dermatol. 1974; 91(6): 607-16[PubMed]
  • 5. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. J Clin Invest. 1995; 95(2): 547-54[DOI][PubMed]
  • 6. Courgnaud V, Duthanh A, Guillot B, Sitbon M, Dereure O. Absence of HTLV-related sequences in skin lesions and peripheral blood of cutaneous T-cell lymphomas. J Invest Dermatol. 2009; 129(10): 2520-2[DOI][PubMed]
  • 7. Nagore E, Ledesma E, Collado C, Oliver V, Perez-Perez A, Aliaga A. Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas. Br J Dermatol. 2000; 143(2): 320-3[PubMed]
  • 8. Herne KL, Talpur R, Breuer-McHam J, Champlin R, Duvic M. Cytomegalovirus seropositivity is significantly associated with mycosis fungoides and Sezary syndrome. Blood. 2003; 101(6): 2132-6[DOI][PubMed]
  • 9. Quereux G, Andre-Garnier E, Knol AC, Imbert-Marcille BM, Dreno B. Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis. Exp Dermatol. 2009; 18(4): 357-61[DOI][PubMed]
  • 10. Ponti R, Bergallo M, Costa C, Quaglino P, Fierro MT, Comessatti A, et al. Human herpesvirus 7 detection by quantitative real time polymerase chain reaction in primary cutaneous T-cell lymphomas and healthy subjects: lack of a pathogenic role. Br J Dermatol. 2008; 159(5): 1131-7[DOI][PubMed]
  • 11. Sander CA, Simon M, Puchta U, Raffeld M, Kind P. HHV-8 in lymphoproliferative lesions in skin. Lancet. 1996; 348(9025): 475-6[DOI][PubMed]
  • 12. Pawson R, Catovsky D, Schulz TF. Lack of evidence of HHV-8 in mature T-cell lymphoproliferative disorders. Lancet. 1996; 348(9039): 1450-1[DOI][PubMed]
  • 13. Henghold WB, 2nd, Purvis SF, Schaffer J, Giam CZ, Wood GS. No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders. J Invest Dermatol. 1997; 108(6): 920-2[PubMed]
  • 14. Dupin N, Franck N, Calvez V, Gorin I, Grandadam M, Huraux JM, et al. Lack of evidence of human herpesvirus 8 DNA sequences in HIV-negative patients with various lymphoproliferative disorders of the skin. Br J Dermatol. 1997; 136(6): 827-30[PubMed]
  • 15. Erkek E, Senturk N, Dincer I, Olut AI, Kocagoz T, Bukulmez G, et al. Identification of herpes simplex virus DNA and lack of human herpesvirus-8 DNA in mycosis fungoides. Acta Derm Venereol. 2002; 82(3): 214-6[PubMed]
  • 16. Trento E, Castilletti C, Ferraro C, Lesnoni La Parola I, Mussi A, Muscardin L, et al. Human herpesvirus 8 infection in patients with cutaneous lymphoproliferative diseases. Arch Dermatol. 2005; 141(10): 1235-42[DOI][PubMed]
  • 17. Kreuter A, Bischoff S, Skrygan M, Wieland U, Brockmeyer NH, Stucker M, et al. High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides. Arch Dermatol. 2008; 144(8): 1011-6[DOI][PubMed]
  • 18. Fahad AS. Prevalence of Human Herpesvirus-8 (HHV-8) in untreated patients with early stage Mycosis Fungoides (A retrospective study). Int J Health Sci (Qassim). 2010; 4(2): 128-38[PubMed]
  • 19. Amitay-Laish I, Sarid R, Ben-Amitai D, Kalt I, Masa SR, David M, et al. Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides. J Am Acad Dermatol. 2012; 66(1): 46-50[DOI][PubMed]
  • 20. Chatlynne LG, Ablashi DV. Seroepidemiology of Kaposi's sarcoma-associated herpesvirus (KSHV). Semin Cancer Biol. 1999; 9(3): 175-85[DOI][PubMed]
  • 21. Gharehbaghian A, Zaghal A, Farhudi Langerudi M, Karimi G. Seroepidemiology of the human Herpesvirus (HHV-8) in the haemodialysis patients blood donors and HIV-positive individuals in City of Tehran. J Sch Pub Health Inst Pub Health Res. 2006; 4: 57-62
  • 22. de Sanjose S, Marshall V, Sola J, Palacio V, Almirall R, Goedert JJ, et al. Prevalence of Kaposi's sarcoma-associated herpesvirus infection in sex workers and women from the general population in Spain. Int J Cancer. 2002; 98(1): 155-8[PubMed]
  • 23. Guttman-Yassky E, Kra-Oz Z, Dubnov J, Friedman-Birnbaum R, Segal I, Zaltzman N, et al. Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with classic Kaposi's sarcoma. Arch Dermatol. 2005; 141(11): 1429-34[DOI][PubMed]
  • 24. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med. 1998; 338(14): 948-54[DOI][PubMed]
  • 25. Cloutier N, van Eyll O, Janelle ME, Lefort S, Gao SJ, Flamand L. Increased tumorigenicity of cells carrying recombinant human herpesvirus 8. Arch Virol. 2008; 153(1): 93-103[DOI][PubMed]
  • 26. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994; 266(5192): 1865-9[PubMed]
  • 27. Cohen SS, Weinstein MD, Herndier BG, Anhalt GJ, Blauvelt A. No evidence of human herpesvirus 8 infection in patients with paraneoplastic pemphigus, pemphigus vulgaris, or pemphigus foliaceus. J Invest Dermatol. 1998; 111(5): 781-3[DOI][PubMed]
  • 28. Fink-Puches R, Zochling N, Wolf P, Back B, Kerl H, Soyer HP. No detection of human herpesvirus 8 in different types of cutaneous angiosarcoma. Arch Dermatol. 2002; 138(1): 131-2[PubMed]
  • 29. Geraminejad P, Memar O, Aronson I, Rady PL, Hengge U, Tyring SK. Kaposi's sarcoma and other manifestations of human herpesvirus 8. J Am Acad Dermatol. 2002; 47(5): 641-55[PubMed]
  • 30. Gyulai R, Kemeny L, Kiss M, Nagy S, Adam E, Nagy F, et al. Human herpesvirus 8 DNA sequences in angiosarcoma of the face. Br J Dermatol. 1997; 137(3): 467[PubMed]
  • 31. Memar OM, Rady PL, Goldblum RM, Yen A, Tyring SK. Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus. Arch Dermatol. 1997; 133(10): 1247-51[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments