Journal of Skin and Stem Cell

Published by: Kowsar

A Review of Acne Etiology and Treatment in Iranian Traditional Medicine

Laila Shirbeigi 1 , Laleh Oveidzadeh 2 , Zahra Jafari 2 , Monireh Sadat Motahari Fard 1 and Parvin Mansouri 3 , *
Authors Information
1 Department of Iranian Traditional Medicine, School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Faculty of Traditional Medicine, Department of Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran
3 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: March 2016, 3 (1); e39133
  • Published Online: February 28, 2016
  • Article Type: Review Article
  • Received: January 1, 2016
  • Revised: February 15, 2016
  • Accepted: March 15, 2016
  • DOI: 10.5812/jssc.39133

To Cite: Shirbeigi L, Oveidzadeh L, Jafari Z, Motahari Fard M S, Mansouri P. A Review of Acne Etiology and Treatment in Iranian Traditional Medicine, J Skin Stem Cell. 2016 ; 3(1):e39133. doi: 10.5812/jssc.39133.

Copyright © 2016, Skin and Stem Cell Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol. 2003; 49(3 Suppl)-10[PubMed]
  • 2. Layton A. Disorders of the Sebaceoum glands. Rook's text book of dermatology. 2010;
  • 3. Fried R, Friedman A. Psychosocial sequelae related to acne: looking beyond the physical. J Drugs Dermatol. 2010; 9(5 Suppl ODAC Conf Pt 1)-2[PubMed]
  • 4. Oberemok SS, Shalita AR. Acne vulgaris, II: treatment. Cutis. 2002; 70(2): 111-4[PubMed]
  • 5. Ghosh VK, Nagore DH, Kadbhane KP, Patil MJ. Different approaches of alternative medicines in acne vulgaris treatment. Orient Pharm Exp Med. 2011; 11(1): 1-9[DOI]
  • 6. Marqueling AL, Zane LT. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review. Semin Cutan Med Surg. 2007; 26(4): 210-20[DOI][PubMed]
  • 7. Enders SJ, Enders JM. Isotretinoin and psychiatric illness in adolescents and young adults. Ann Pharmacother. 2003; 37(7-8): 1124-7[PubMed]
  • 8. AgiliKhorasani MH. Kholase Al- Hekme [ in Persian ]. 2006;
  • 9. Jackson WA. A short guide to humoral medicine. Trends Pharmacol Sci. 2001; 22(9): 487-9[PubMed]
  • 10. Kitab al- Qanun Fi al- tibb( Canon of Medicine Tehran) [in Persian]. 1988; 3
  • 11. Shah- Arzani MA. Tibb - e- Akbari ( Akbar's Medicine). 2008;
  • 12. Mojahedi M, Naseri M, Majdzadeh R, Keshavarz M, Ebadini M, Nazem E, et al. Reliability and Validity Assessment of Mizaj Questionnaire: A Novel Self-report Scale in Iranian Traditional Medicine. Iran Red Crescent Med J. 2014; 16(3): 15924[DOI][PubMed]
  • 13. Farsani G, Movahhed M, Motlagh A, Hosseini S, Yunesian M, Farsani T, et al. Is the Iranian Traditional Medicine warm and cold temperament related to Basal Metabolic Rate and activity of the sympathetic-parasympathetic system? Study protocol. J Diabet Metabol Disorder. 2014; 13(1): 74[DOI]
  • 14. Zarshenas M, Khademian S, Moein M. Diabetes and related remedies in medieval Persian medicine. Indian J Endo Metabol. 2014; 18(2): 142[DOI]
  • 15. Yosefi SS, Moradi Kor N, Sadeghpour O, Jokar A, Askarfarashah M. New aspects to digestive process and importance of stomach as basic cause for disease. Euro J Exp Biol. 2014; 4(3): 209-10
  • 16. Shirbeigi L, Iranzadasl M, Mansouri P, Hejazi S, Aliasl J. Skin Aging Remedies in Traditional Persian Medicine. J Skin Stem Cell. 2015; 2(1)[DOI]
  • 17. Naseri M. The school of traditional Iranian medicine: The definition, origin and advantages. Iran J Pharm Res. 2010; : 20-3
  • 18. Hernandez-Ledesma B, Hsieh CC, de Lumen BO. Chemopreventive properties of Peptide Lunasin: a review. Protein Pept Lett. 2013; 20(4): 424-32[PubMed]
  • 19. Jeong HJ, Jeong JB, Hsieh CC, Hernández-Ledesma B, de Lumen BO. Lunasin Is Prevalent in Barley and Is Bioavailable and Bioactive in In Vivo and In Vitro Studies. Nutr Cancer. 2010; 62(8): 1113-9[DOI]
  • 20. Spencer EH, Ferdowsian HR, Barnard ND. Diet and acne: a review of the evidence. Int J Dermatol. 2009; 48(4): 339-47[DOI][PubMed]
  • 21. El-Akawi Z, Abdel-Latif Nemr N, Abdul-Razzak K, Al-Aboosi M. Factors believed by Jordanian acne patients to affect their acne condition. East Mediterr Health J. 2006; 12(6): 840-6[PubMed]
  • 22. Letter: "Iatrogenic": etymologic riposte. N Engl J Med. 1976; 295(3): 175-6[PubMed]
  • 23. Callen JP, Wortmann RL. Dermatomyositis. Dermatol. 2006; 24(5): 363-73
  • 24. Mullika TC, Suvimol S, Veena SN, Wandee G. Fitotherapia 782007. : 401-8
  • 25. Azadegan H. Synergistic effect of water extract of sumac( Rhus coriaria L.) on some antibiotics against propioni bacterium acne skin isolate.Msc thesis [in Persian].
  • 26. Mamelak AJ, Jackson A, Nizamani R, Arnon O, Liegeois NJ, Redett RJ, et al. Leech therapy in cutaneous surgery and disease. J Drugs Dermatol. 2010; 9(3): 252-7[PubMed]
  • 27. Zoe DD. The ability of onion extract gel to improve the cosmetic appearance of post- surgical scars. J Cosmetic Dermatol. 2008; 7(2): 101-4[DOI]
  • 28. Arabbi PR, Genovese MI, Lajolo FM. Flavonoids in vegetable foods commonly consumed in Brazil and estimated ingestion by the Brazilian population. J Agric Food Chem. 2004; 52(5): 1124-31[DOI][PubMed]
  • 29. Kim JH. Anti-bacterial action of onion (Allium cepa L.) extracts against oral pathogenic bacteria. J Nihon Univ Sch Dent. 1997; 39(3): 136-41[PubMed]
  • 30. Abbas ZK, Saggu S, Sakeran MI, Zidan N, Rehman H, Ansari AA. Phytochemical, antioxidant and mineral composition of hydroalcoholic extract of chicory (Cichorium intybus L.) leaves. Saudi J Biol Sci. 2015; 22(3): 322-6[DOI][PubMed]
  • 31. Street RA, Sidana J, Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evid Based Complement Alternat Med. 2013; 2013: 579319[DOI][PubMed]
  • 32. Casetti F, Bartelke S, Biehler K, Augustin M, Schempp CM, Frank U. Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum L. fruits. Phytother Res. 2012; 26(3): 420-4[DOI][PubMed]
  • 33. Hwang E, Lee DG, Park SH, Oh MS, Kim SY. Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. J Med Food. 2014; 17(9): 985-95[DOI][PubMed]
  • 34. Khan H, Akhtar N, Ali A. Effects of Cream Containing Ficus carica L. Fruit Extract on Skin Parameters: In vivo Evaluation. Indian J Pharm Sci. 2014; 76(6): 560-4[PubMed]
  • 35. Wolosik K, Markowska A, Kuzmicz I. Lunasin--a novel chemopreventive peptide [ in Polish ]. Postepy Biochem. 2014; 60(1): 84-9[PubMed]
  • 36. Misir R, Blair R. Effect of biotin supplementation of a barley-wheat diet on restoration of healthy feet, legs and skin of biotin deficient sows. Res Vet Sci. 1986; 40(2): 212-8[PubMed]
  • 37. De Spirt S, Stahl W, Tronnier H, Sies H, Bejot M, Maurette JM, et al. Intervention with flaxseed and borage oil supplements modulates skin condition in women. Br J Nutr. 2009; 101(3): 440-5[DOI][PubMed]
  • 38. Lee SH, Heo Y, Kim YC. Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice. J Vet Sci. 2010; 11(1): 35-41[PubMed]
  • 39. Munir N, Iqbal A, Altaf I, Bashir R, Sharif N, Saleem F, et al. Evaluation of antioxidant and antimicrobial potential of two endangered plant species Atropiabelladonna and MatricariaChamomilla. Afr J Tradit Complement Altern Med. 2014; 11(5): 111-7
  • 40. Dikmen M, Ozturk N, Ozturk Y. The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer. J Med Food. 2011; 14(12): 1638-46[DOI][PubMed]
  • 41. Afaq F, Khan N, Syed DN, Mukhtar H. Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Photochem Photobiol. 2010; 86(6): 1318-26[DOI][PubMed]
  • 42. Kasai K, Yoshimura M, Koga T, Arii M, Kawasaki S. Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin. J Nutr Sci Vitaminol (Tokyo). 2006; 52(5): 383-8[PubMed]
  • 43. Del Rosso JQ. Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004; 73(1 Suppl): 29-33[PubMed]
  • 44. Karodi RS, Mahendrakumar CB, Bhise K. Evaluation of anti-acne activity of hydroalcoholic extract of Punica granatum Linn. J Pharma Phytoth. 2013; 5(9): 160-3
  • 45. ozkan G. Note: Antioxidant and Antibacterial Activities of Rosa Damascena Flower Extracts. Food Sci Technol Int. 2004; 10(4): 277-81[DOI]
  • 46. Tofighi Z, Molazem M, Doostdar B, Taban P, Shahverdi AR, Samadi N, et al. Antimicrobial Activities of Three Medicinal Plants and Investigation of Flavonoids of Tripleurospermum disciforme. Iran J Pharm Res. 2015; 14(1): 225-31[PubMed]
  • 47. Yassa N, Masoomi F, RohaniRankouhi SE, Hadjiakhoondi A. Chemical composition and antioxidant activity of the extract and assential oil of Rosa Damascina from Iran, population of Gilan [in Persian]. Daru. 2009; 17: 175-80
  • 48. Tabrizi H, Mortazavi SA, Kamalinejad M. An in vitro evaluation of various Rosa damascena flower extracts as a natural antisolar agent. Int J Cosmet Sci. 2003; 25(6): 259-65[DOI][PubMed]
  • 49. Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, et al. Tannin extracts from immature fruits of Terminalia Chebula fructose Retz. promodecutaneus wound healing in rats. BMC Complementary Altern Med. 2011; 11(86)[DOI]
  • 50. Manosroi A, Jantrawut P, Akihisa T, Manosroi W, Manosroi J. In vitro and in vivo skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula galls. Pharm Biol. 2011; 49(11): 1190-203[DOI][PubMed]
  • 51. Ahmad I, Beg AZ. Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. J Ethnopharmacol. 2001; 74(2): 113-23[PubMed]
  • 52. Aqil F, Ahmad I, Mehmood Z. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turkish J Biol. 2006; 30(3): 177-83
  • 53. Bae MJ, Shin HS, Choi DW, Shon DH. Antiallergic effect of Trigonella foenum-graecum L. extracts on allergic skin inflammation induced by trimellitic anhydride in BALB/c mice. J Ethnopharmacology. 2012; 144(3): 514-22[DOI]
  • 54. Abdel- Massih R, Abdou E, Baydoun E. Antibacterial activity of the extracts obtained from Rosmarinus officinalis, Origanummajorana, and Trigonella foenum- graecum on highly drug- resistance gram negative bacilli. J Botany. 2010;
  • 55. Dweck AC. Isoflavones, phytohormones and phytosterols. J ApplCosmetol. 2006; 24: 17-33
  • 56. Guillou S, Ghabri S, Jannot C, Gaillard E, Lamour I, Boisnic S. The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. Int J Cosmet Sci. 2011; 33(2): 138-43[DOI][PubMed]
  • 57. Kapoor S, Saraf S. Assessment of viscoelasticity and hydration effect of herbal moisturizers using bioengineering techniques. Pharmacogn Mag. 2010; 6(24): 298-304[DOI][PubMed]
  • 58. Rimkiene S, Ragazinskiene O, Savickiene N. The cumulation of Wild pansy (Viola tricolor L.) accessions: the possibility of species preservation and usage in medicine. Medicina (Kaunas). 2003; 39(4): 411-6[PubMed]
  • 59. Khazaeli P, Mehrabani M. Screening of sun protective activity of the ethyl acetate extracts of some medicinal plants. Iran J Pharma Res. 2010; 7(1): 5-9
  • 60. Kapoor S, Saraf S. Topical Herbal Therapies an Alternative and Complementary Choice to Combat Acne. Res J Med Plant. 2011; 5(6): 650-9[DOI]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments