Journal of Skin and Stem Cell

Published by: Kowsar

IFN-γ Promotes Apoptosis of Melanocytes in Vitiligo

Zohreh Jadali 1 , 2 , *
Author Information
1 Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Skin and Stem Cell: December 31, 2015, 2 (4); e35719
  • Published Online: December 28, 2015
  • Article Type: Letter
  • Received: July 18, 2015
  • Accepted: September 19, 2015
  • DOI: 10.17795/jssc35719

To Cite: Jadali Z. IFN-γ Promotes Apoptosis of Melanocytes in Vitiligo, J Skin Stem Cell. 2015 ; 2(4):e35719. doi: 10.17795/jssc35719.

Copyright © 2015, Skin and Stem Cell Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
References
  • 1. Lili Y, Yi W, Ji Y, Yue S, Weimin S, Ming L. Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo. PLoS One. 2012; 7(5)[DOI][PubMed]
  • 2. Nouri-Koupaee A, Mansouri P, Jahanbini H, Sanati MH, Jadali Z. Differential expression of mRNA for T-bet and GATA-3 transcription factors in peripheral blood mononuclear cells of patients with vitiligo. Clin Exp Dermatol. 2015; 40(7): 735-40[DOI][PubMed]
  • 3. Wu J, Zhou M, Wan Y, Xu A. CD8+ T cells from vitiligo perilesional margins induce autologous melanocyte apoptosis. Mol Med Rep. 2013; 7(1): 237-41[DOI][PubMed]
  • 4. Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol. 2008; 9(9): 970-80[DOI][PubMed]
  • 5. Ekkens MJ, Shedlock DJ, Jung E, Troy A, Pearce EL, Shen H, et al. Th1 and Th2 cells help CD8 T-cell responses. Infect Immun. 2007; 75(5): 2291-6[DOI][PubMed]
  • 6. Yang L, Wei Y, Sun Y, Shi W, Yang J, Zhu L, et al. Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo. Acta Derm Venereol. 2015; 95(6): 664-70[DOI][PubMed]
  • 7. Natarajan VT, Ganju P, Singh A, Vijayan V, Kirty K, Yadav S, et al. IFN-gamma signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation. Proc Natl Acad Sci U S A. 2014; 111(6): 2301-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments