Journal of Skin and Stem Cell

Published by: Kowsar

Effects of Wet Cupping on Blood Components Specially Skin-Related Parameters of Healthy Cases: A Case Control Metabonomic Study

Mehdi Fahimi 1 , Nooshafarin Kazemikhoo 2 , * , Fataneh Hashem Dabaghian 3 , Ayda Iravani 4 , Farideh Vahabi 4 , Mehri Azadi 4 , Sedigheh Sadeghi 4 , Fahimeh Mirkhani 4 , Mohammad Arjmand 4 , Zahra Zamani 4 , ** , Fereshteh Ansari 5 and Roshanak Gods 3
Authors Information
1 Iranian Maad Traditional Medicine Clinic, Tehran, Iran
2 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Department of Biochemistry, Pasteur institute of Iran, Tehran, Iran
5 Fereshteh Ansari Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Corresponding Authors:
Article information
  • Journal of Skin and Stem Cell: June 2016, 3 (2); e12654
  • Published Online: June 21, 2016
  • Article Type: Research Article
  • Received: April 4, 2016
  • Accepted: May 16, 2016
  • DOI: 10.5812/jssc.12654

To Cite: Fahimi M, Kazemikhoo N, Hashem Dabaghian F, Iravani A, Vahabi F, et al. Effects of Wet Cupping on Blood Components Specially Skin-Related Parameters of Healthy Cases: A Case Control Metabonomic Study, J Skin Stem Cell. 2016 ;3(2):e12654. doi: 10.5812/jssc.12654.

Copyright: Copyright © 2016, Journal of Skin and Stem Cell. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Gao LW. Practical cupping therapy. Beijing, China: Beijing, Academy Press; 2004.
  • 2. Cao H, Zhu C, Liu J. Wet cupping therapy for treatment of herpes zoster: a systematic review of randomized controlled trials. Altern Ther Health Med. 2010;16(6):48-54. [PubMed: 21280462].
  • 3. Gruner OC. A treatise on the canon of medicine of avicenna, incorporating a translation of the first book. 1 ed. London: Luzac and Co; 1970.
  • 4. Christopoulou-Aletra H, Papavramidou N. Cupping: an alternative surgical procedure used by Hippocratic physicians. J Altern Complement Med. 2008;14(8):899-902. doi: 10.1089/acm.2008.0238. [PubMed: 18925866].
  • 5. Kim JI, Lee MS, Lee DH, Boddy K, Ernst E. Cupping for treating pain, A systematic review. Evid Based Complement Alternat Med. 2011;2011:1-7. doi: 10.1093/ecam/nep035.
  • 6. AlBedah A, Khalil M, Elolemy A, Elsubai I, Khalil A. Hijama (cupping), A review of the evidence. Focus Altern Complement Ther. 2011;16(1):12-6. doi: 10.1111/j.2042-7166.2010.01060.x.
  • 7. Cao H, Han M, Li X, Dong S, Shang Y, Wang Q, et al. Clinical research evidence of cupping therapy in China: a systematic literature review. BMC Complement Altern Med. 2010;10:70. doi: 10.1186/1472-6882-10-70. [PubMed: 21078197].
  • 8. Ahmadi A, Schwebel DC, Rezaei M. The efficacy of wet-cupping in the treatment of tension and migraine headache. Am J Chin Med. 2008;36(1):37-44. doi: 10.1142/S0192415X08005564. [PubMed: 18306448].
  • 9. Lee MS, Choi TY, Shin BC, Kim JI, Nam SS. Cupping for hypertension: a systematic review. Clin Exp Hypertens. 2010;32(7):423-5. doi: 10.3109/10641961003667955. [PubMed: 20828224].
  • 10. Ahmed SM, Madbouly NH, Maklad SS, Abu-Shady EA. Immunomodulatory effects of blood letting cupping therapy in patients with rheumatoid arthritis. Egypt J Immunol. 2005;12(2):39-51. [PubMed: 17977209].
  • 11. Farhadi K, Schwebel DC, Saeb M, Choubsaz M, Mohammadi R, Ahmadi A. The effectiveness of wet-cupping for nonspecific low back pain in Iran: a randomized controlled trial. Complement Ther Med. 2009;17(1):9-15. doi: 10.1016/j.ctim.2008.05.003. [PubMed: 19114223].
  • 12. Zarei M, Hejazi S, Javadi SA, Farahani H. The efficacy of wet cupping in the treatment of hypertension. ARYA Atheroscler. 2012:145-8.
  • 13. Chirali I. The cupping procedure. Traditional chinese medicine cupping therapy. London, United Kingdom: Churchill Livingstone; 1999.
  • 14. Wang J, Reijmers T, Chen L, Van Der Heijden R, Wang M, Peng S, et al. Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics. Metabolomics. 2009;5(4):407-18. doi: 10.1007/s11306-009-0165-3. [PubMed: 20046867].
  • 15. Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999;42(1):113-6. doi: 10.1007/s001250051123. [PubMed: 10027589].
  • 16. Stepisnik J, Lasic S, Mohoric A, Sersa I, Sepe A. Spectral characterization of diffusion in porous media by the modulated gradient spin echo with CPMG sequence. J Magn Reson. 2006;182(2):195-9. doi: 10.1016/j.jmr.2006.06.023. [PubMed: 16844392].
  • 17. Wold S, Sjostrom M, Eriksson L. PLS regression, a basic tool of chemometrics. Chemometr Intell Lab Syst. 2001;58(2):109-30. doi: 10.1016/s0169-7439(01)00155-1.
  • 18. Fearn T. On orthogonal signal correction. Chemometrics Intelligent Laboratory Systems. 2000;50(1):47-52. doi: 10.1016/s0169-7439(99)00045-3.
  • 19. Xia J, Psychogios N, Young N, Wishart DS. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res. 2009;37(Web Server issue):652-60. doi: 10.1093/nar/gkp356. [PubMed: 19429898].
  • 20. Hashem Dabaghian F, Gousheh GS, Siadati S. Assessment of the frequency of hejamat centers and characteristics of their clients, Tehran 2006. J Iran Univmed Sci. 2008;15(58).
  • 21. Shumay DM, Maskarinec G, Gotay CC, Heiby EM, Kakai H. Determinants of the degree of complementary and alternative medicine use among patients with cancer. J Altern Complement Med. 2002;8(5):661-71. doi: 10.1089/107555302320825183. [PubMed: 12470448].
  • 22. Easthope G, Tranter B, Gill G. Normal medical practice of referring patients for complementary therapies among Australian general practitioners. Complement Ther Med. 2000;8(4):226-33. doi: 10.1054/ctim.2000.0398. [PubMed: 11098197].
  • 23. Bilal M, Khan RA, Ahmed A, Afroz A. Partial evaluation of technique use d in cupping therapy. J Basic Appl Sci. 2011;7(1):65-8.
  • 24. Niasari M, Kosari F, Ahmadi A. The effect of wet cupping on serum lipid concentrations of clinically healthy young men: a randomized controlled trial. J Altern Complement Med. 2007;13(1):79-82. doi: 10.1089/acm.2006.4226. [PubMed: 17309381].
  • 25. Aoki H, Kamachi H. Hair nourishing cosmetic, Google patents. Application: Denko, S. K. K; 2009.
  • 26. Arias-Santiago S, Gutierrez-Salmeron MT, Buendia-Eisman A, Giron-Prieto MS, Naranjo-Sintes R. Hypertension and aldosterone levels in women with early-onset androgenetic alopecia. Br J Dermatol. 2010;162(4):786-9. doi: 10.1111/j.1365-2133.2009.09588.x. [PubMed: 19906217].
  • 27. El Domyati M, Saleh F, Barakat M, Mohamed N. Evaluation of cupping therapy in some dermatoses. Egyptian Dermatol Online J. 2013;9(1):2.
  • 28. Cao H, Yang G, Wang Y, Liu JP, Smith CA, Luo H, et al. Complementary therapies for acne vulgaris. London, United Kingdom: The Cochrane Library; 2015. doi: 10.1002/14651858.CD009436.pub2.
  • 29. Pan H. Thirty-two cases of acne treated with blood-letting puncture, cupping and Chinese-drug facemask. J Tradit Chin Med. 2005;25(4):270-2. [PubMed: 16447668].
  • 30. Rozenfeld E, Kalichman L. New is the well-forgotten old: The use of dry cupping in musculoskeletal medicine. J Bodyw Mov Ther. 2016;20(1):173-8. doi: 10.1016/j.jbmt.2015.11.009. [PubMed: 26891653].
  • 31. Mehta P, Dhapte V. Cupping therapy: A prudent remedy for a plethora of medical ailments. J Tradit Complement Med. 2015;5(3):127-34. doi: 10.1016/j.jtcme.2014.11.036. [PubMed: 26151023].
  • 32. Tagil SM, Celik HT, Ciftci S, Kazanci FH, Arslan M, Erdamar N, et al. Wet-cupping removes oxidants and decreases oxidative stress. Complement Ther Med. 2014;22(6):1032-6. doi: 10.1016/j.ctim.2014.10.008. [PubMed: 25453524].
  • 33. Ludtke R, Albrecht U, Stange R, Uehleke B. Brachialgia paraesthetica nocturna can be relieved by "wet cupping"--results of a randomised pilot study. Complement Ther Med. 2006;14(4):247-53. doi: 10.1016/j.ctim.2006.07.004. [PubMed: 17105694].
  • 34. Lee MS, Choi TY, Shin BC, Han CH, Ernst E. Cupping for stroke rehabilitation: a systematic review. J Neurol Sci. 2010;294(1-2):70-3. doi: 10.1016/j.jns.2010.03.033. [PubMed: 20435319].
  • 35. Michalsen A, Bock S, Ludtke R, Rampp T, Baecker M, Bachmann J, et al. Effects of traditional cupping therapy in patients with carpal tunnel syndrome: a randomized controlled trial. J Pain. 2009;10(6):601-8. doi: 10.1016/j.jpain.2008.12.013. [PubMed: 19380259].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader