Journal of Skin and Stem Cell Journal of Skin and Stem Cell J Skin Stem Cell http://www.journalssc.com 2423-7086 10.5812/jssc. en jalali 2017 6 26 gregorian 2017 6 26 2 3
en 10.17795/jssc30787 Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa review-article review-article Context

Connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. These cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body.

Evidence Acquisition

Connective tissue cells play a central role in supporting as well as repairing tissues and organs. Fibroblast cell therapy could be used for the treatment of burn wounds, scars, diabetic foot ulcers, acne scars and skin aging. This review focused on biology of fibroblasts and their role in cell therapy of recessive dystrophic epidermolysis bullosa (RDEB).

Results

Fibroblasts are known to play a pivotal role in skin structure and integrity, and dermal fibroblasts are believed to promote skin regeneration and rejuvenation via collagen production.

Conclusions

Fibroblasts can be used in transplantations to ameliorate an immune system response, in order to reduce antigen production. Human fibroblasts suppress ongoing mixed lymphocyte reactions (MLRs) between lymphocyte cells from two individuals, and supernatant materials from fibroblast cultures suppress MLRs.

Context

Connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. These cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body.

Evidence Acquisition

Connective tissue cells play a central role in supporting as well as repairing tissues and organs. Fibroblast cell therapy could be used for the treatment of burn wounds, scars, diabetic foot ulcers, acne scars and skin aging. This review focused on biology of fibroblasts and their role in cell therapy of recessive dystrophic epidermolysis bullosa (RDEB).

Results

Fibroblasts are known to play a pivotal role in skin structure and integrity, and dermal fibroblasts are believed to promote skin regeneration and rejuvenation via collagen production.

Conclusions

Fibroblasts can be used in transplantations to ameliorate an immune system response, in order to reduce antigen production. Human fibroblasts suppress ongoing mixed lymphocyte reactions (MLRs) between lymphocyte cells from two individuals, and supernatant materials from fibroblast cultures suppress MLRs.

Cell Therapy;Allogeneic Transplantation;Fibroblasts;Epidermolysis Bullosa Cell Therapy;Allogeneic Transplantation;Fibroblasts;Epidermolysis Bullosa http://www.journalssc.com/index.php?page=article&article_id=30787 Sona Zare Sona Zare Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Reza Ahmadi Reza Ahmadi Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IR Iran Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IR Iran Ayoob Rostamzadeh Ayoob Rostamzadeh Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran Soleiman Kurd Soleiman Kurd School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Somayeh Hejazi Somayeh Hejazi Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Maryam Fard Maryam Fard Department of Anatomical Science, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran Department of Anatomical Science, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran Maryam Anjomshoa Maryam Anjomshoa Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran; Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran. Tel: +98-3813335652, Fax: +98-3813334911 Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran; Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran. Tel: +98-3813335652, Fax: +98-3813334911 Mohammad Ali Nilforoushzadeh Mohammad Ali Nilforoushzadeh Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran. Tel: +98-2122674977, Fax: +98-2122239264 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran. Tel: +98-2122674977, Fax: +98-2122239264
en 10.17795/jssc35681 Injection of Autologous Fat Alone and in Combination With Autologous Platelet Gel for Nasolabial Fold Augmentation Injection of Autologous Fat Alone and in Combination With Autologous Platelet Gel for Nasolabial Fold Augmentation research-article research-article Results

All patients experienced improvement in the wrinkles of the side treated by the combination therapy compared to the other side. In addition, less complication was observed in the side that underwent combination therapy.

Conclusions

Our study showed that autologous fat in combination with platelet gel might have better cosmetic results as well as lesser complications in the healing of nasolabial wrinkles. However, the findings of this pilot study should be examined in further studies with larger sample size.

Patients and Methods

Nine volunteers (three males and six females) were referred to the dermatology clinic of Rasoul-e-Akram hospital. For each patient, one side of the lateral nasolabial folds underwent injections with the combination of autologous fat and platelet gel and the other side with autologous fat alone. Improvement of nasolabial fold was monitored by clinical assessment and digital photographs over a six-month period.

Background

Recently, soft tissue augmentation has become popular due to development of convenient techniques. Autologous fat is one of the safest fillers for this purpose. Moreover, healing effects of autologous platelet gel on acute and chronic human skin wounds have been shown in recent studies.

Objectives

In this study, the effect of subcutaneous injection of autologous fat alone and in combination with platelet gel was compared in the treatment of nasolabial skin folds in nine cases.

Results

All patients experienced improvement in the wrinkles of the side treated by the combination therapy compared to the other side. In addition, less complication was observed in the side that underwent combination therapy.

Conclusions

Our study showed that autologous fat in combination with platelet gel might have better cosmetic results as well as lesser complications in the healing of nasolabial wrinkles. However, the findings of this pilot study should be examined in further studies with larger sample size.

Patients and Methods

Nine volunteers (three males and six females) were referred to the dermatology clinic of Rasoul-e-Akram hospital. For each patient, one side of the lateral nasolabial folds underwent injections with the combination of autologous fat and platelet gel and the other side with autologous fat alone. Improvement of nasolabial fold was monitored by clinical assessment and digital photographs over a six-month period.

Background

Recently, soft tissue augmentation has become popular due to development of convenient techniques. Autologous fat is one of the safest fillers for this purpose. Moreover, healing effects of autologous platelet gel on acute and chronic human skin wounds have been shown in recent studies.

Objectives

In this study, the effect of subcutaneous injection of autologous fat alone and in combination with platelet gel was compared in the treatment of nasolabial skin folds in nine cases.

Fat Injection;Filler;Platelet Fat Injection;Filler;Platelet http://www.journalssc.com/index.php?page=article&article_id=35681 Babak Ghasemi Babak Ghasemi Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Seyed Mehdi Tabaie Seyed Mehdi Tabaie Medical Laser Research Center, ACECR, Tehran, Iran; Medical Laser Research Center, ACECR, Tehran, Iran. Tel: +98-2166402020, Fax: +98-2166402020 Medical Laser Research Center, ACECR, Tehran, Iran; Medical Laser Research Center, ACECR, Tehran, Iran. Tel: +98-2166402020, Fax: +98-2166402020 MirHadi Azizjalali MirHadi Azizjalali Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Hoda Berenjiardestani Hoda Berenjiardestani Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohammad Fereshtenejad Seyed Mohammad Fereshtenejad Firoozgar Clinical Research Development Center, Tehran University of Medical Sciences, Tehran, Iran Firoozgar Clinical Research Development Center, Tehran University of Medical Sciences, Tehran, Iran Naser Amirizadeh Naser Amirizadeh Research Center of Iranian Blood Transfusion Organization, Tehran, Iran Research Center of Iranian Blood Transfusion Organization, Tehran, Iran Mohsen Fateh Mohsen Fateh Medical Laser Research Center, ACECR, Tehran, Iran Medical Laser Research Center, ACECR, Tehran, Iran
en 10.17795/jssc30817 Dermatological Disorders Caused by Middle East Respiratory Syndrome Dermatological Disorders Caused by Middle East Respiratory Syndrome letter letter Dermatological Problems;Middle East Respiratory Syndrome Dermatological Problems;Middle East Respiratory Syndrome http://www.journalssc.com/index.php?page=article&article_id=30817 Hai Err Hai Err Medical Center, Sanitation 1 Medical Academic Center, Bangkok, Thailand; Medical Center, Sanitation 1 Medical Academic Center, Bangkok, Thailand. Tel: +66-892347765, Fax: +66-892347765 Medical Center, Sanitation 1 Medical Academic Center, Bangkok, Thailand; Medical Center, Sanitation 1 Medical Academic Center, Bangkok, Thailand. Tel: +66-892347765, Fax: +66-892347765 Viroj Wiwanitkit Viroj Wiwanitkit Tropical Medicine Unit, Hainan Medical University, Haikou, China Tropical Medicine Unit, Hainan Medical University, Haikou, China
en 10.17795/jssc31934 Signaling Molecules as Promising Drug Targets for the Treatment of Psoriasis Signaling Molecules as Promising Drug Targets for the Treatment of Psoriasis letter letter Genetic Engineering;Janus Kinases;Psoriasis Genetic Engineering;Janus Kinases;Psoriasis http://www.journalssc.com/index.php?page=article&article_id=31934 Zohreh Jadali Zohreh Jadali Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98-2122215558, Fax: +98-2122239264 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98-2122215558, Fax: +98-2122239264
en 10.17795/jssc33472 Impetigo After Actinic Keratosis Treatment With Ingenol Mebutate Gel: An Important Complication Impetigo After Actinic Keratosis Treatment With Ingenol Mebutate Gel: An Important Complication letter letter Actinic Keratosis;Skin Cancer;Ingenol Mebutate;Impetigo Actinic Keratosis;Skin Cancer;Ingenol Mebutate;Impetigo http://www.journalssc.com/index.php?page=article&article_id=33472 Dennis A. Porto Dennis A. Porto Department of Dermatology, Henry Ford Health System, Detroit, USA; Department of Dermatology, Henry Ford Health System, Detroit, USA Department of Dermatology, Henry Ford Health System, Detroit, USA; Department of Dermatology, Henry Ford Health System, Detroit, USA Matteo C LoPiccolo Matteo C LoPiccolo Department of Dermatology, Henry Ford Health System, Detroit, USA; The Toledo Clinic Inc, Ohio, USA Department of Dermatology, Henry Ford Health System, Detroit, USA; The Toledo Clinic Inc, Ohio, USA David J Kouba David J Kouba The Toledo Clinic Inc, Ohio, USA The Toledo Clinic Inc, Ohio, USA