Journal of Skin and Stem Cell Journal of Skin and Stem Cell J Skin Stem Cell http://www.journalssc.com 2423-7086 10.5812/jssc. en jalali 2017 6 24 gregorian 2017 6 24 1 3
en 10.17795/jssc25808 Analysis of Risk Factors for Psoriasis Recurrence Using Proportional Rates Model Analysis of Risk Factors for Psoriasis Recurrence Using Proportional Rates Model research-article research-article Conclusions

It is essential to identify people with psoriasis. Another important point is to inform patients of the causes of this disease to decrease the risk of recurrence. In addition, it is recommended to educate patients about reduction or cessation of smoking as a part of psoriasis treatment.

Results

The results of this study indicated that infection, stress, family history, blood calcium level, smoking, and number of white blood cells were risk factors for recurrence of psoriasis. Moreover, 56.3% of patients did not have any leading-to-hospitalization relapse after enrolling in the study with one relapse episode reported in 23%, two in 10.6%, three in 4.4%, and four or more relapse episodes in 5.6% of participants.

Patients and Methods

The current study was conducted at the Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, from March 2006 through April 2014. A total of 160 patients with confirmed diagnosis of psoriasis were recruited and risk factors for the recurrence of psoriasis were identified and evaluated by applying the proportional rates model.

Background

Psoriasis is a chronic, recurrent, genetic skin disease without any definite cure. Unfortunately, studies on psoriasis are limited in our country and few studies have been done regarding its risk factors and time of occurrence.

Objectives

The current study aimed to assess risk factors of psoriasis recurrence through proportional rates model.

Conclusions

It is essential to identify people with psoriasis. Another important point is to inform patients of the causes of this disease to decrease the risk of recurrence. In addition, it is recommended to educate patients about reduction or cessation of smoking as a part of psoriasis treatment.

Results

The results of this study indicated that infection, stress, family history, blood calcium level, smoking, and number of white blood cells were risk factors for recurrence of psoriasis. Moreover, 56.3% of patients did not have any leading-to-hospitalization relapse after enrolling in the study with one relapse episode reported in 23%, two in 10.6%, three in 4.4%, and four or more relapse episodes in 5.6% of participants.

Patients and Methods

The current study was conducted at the Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, from March 2006 through April 2014. A total of 160 patients with confirmed diagnosis of psoriasis were recruited and risk factors for the recurrence of psoriasis were identified and evaluated by applying the proportional rates model.

Background

Psoriasis is a chronic, recurrent, genetic skin disease without any definite cure. Unfortunately, studies on psoriasis are limited in our country and few studies have been done regarding its risk factors and time of occurrence.

Objectives

The current study aimed to assess risk factors of psoriasis recurrence through proportional rates model.

Psoriasis;Recurrence;Survival rates Psoriasis;Recurrence;Survival rates http://www.journalssc.com/index.php?page=article&article_id=25808 Parvin Mansouri Parvin Mansouri Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Ebrahim Hajizadeh Ebrahim Hajizadeh Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, P.O. Box:14115-331, Tehran, Iran. Tel: +98-2182883810 Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, P.O. Box:14115-331, Tehran, Iran. Tel: +98-2182883810 Freshteh Osmani Freshteh Osmani Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
en 10.17795/jssc23330 Treatment of Acne Vulgaris Using the Combination of Topical Erythromycin and Miconazole Treatment of Acne Vulgaris Using the Combination of Topical Erythromycin and Miconazole research-article research-article Background

Acne vulgaris is a multifactorial disease of the pilosebaceous unit. Malassezia furfur is one of the causative agents of the disease.It provides a proper environment for Propionibacterium to grow. Miconazole inhibits the Propionibacterium growth by its fungicidal activity.

Objectives

The aim of this study was to evaluate the treatment of Acne vulgaris using the combination of topical erythromycin and miconazole.

Patients and Methods

In a single-blinded randomized clinical trial, 60 patients who were referred to the dermatology clinics of Isfahan University of Medical Sciences with mild to moderate acne vulgaris were selected by simple random sampling method. The patients were randomly allocated to two groups. One group was treated with 2% erythromycin alcoholic solution and the other group was treated with 2% erythromycin and 2% miconazole alcoholic solution. Patients were followed up each month for three months. The efficacy of treatment was evaluated by the Acne Severity Index (ASI) and the data were analyzed by the SPSS.

Results

In the second and the third months of treatment, ASI and inflammatory acne lesions significantly reduced in the erythromycin plus miconazole group in comparison to the erythromycin group (P < 0.05). Efficacy of erythromycin plus miconazole in reduction of acne lesions was moderate and excellent in the second and third months of treatment, respectively. Both treatment methods were highly effective in reducing the inflammatory lesions (papules and pustules) and were least effective in noninflammatory lesions (comedones).

Conclusions

This study showed that erythromycin plus miconazole alcoholic solution is effective in treating the mild to moderate acne lesions as an adjuvant therapy.

Background

Acne vulgaris is a multifactorial disease of the pilosebaceous unit. Malassezia furfur is one of the causative agents of the disease.It provides a proper environment for Propionibacterium to grow. Miconazole inhibits the Propionibacterium growth by its fungicidal activity.

Objectives

The aim of this study was to evaluate the treatment of Acne vulgaris using the combination of topical erythromycin and miconazole.

Patients and Methods

In a single-blinded randomized clinical trial, 60 patients who were referred to the dermatology clinics of Isfahan University of Medical Sciences with mild to moderate acne vulgaris were selected by simple random sampling method. The patients were randomly allocated to two groups. One group was treated with 2% erythromycin alcoholic solution and the other group was treated with 2% erythromycin and 2% miconazole alcoholic solution. Patients were followed up each month for three months. The efficacy of treatment was evaluated by the Acne Severity Index (ASI) and the data were analyzed by the SPSS.

Results

In the second and the third months of treatment, ASI and inflammatory acne lesions significantly reduced in the erythromycin plus miconazole group in comparison to the erythromycin group (P < 0.05). Efficacy of erythromycin plus miconazole in reduction of acne lesions was moderate and excellent in the second and third months of treatment, respectively. Both treatment methods were highly effective in reducing the inflammatory lesions (papules and pustules) and were least effective in noninflammatory lesions (comedones).

Conclusions

This study showed that erythromycin plus miconazole alcoholic solution is effective in treating the mild to moderate acne lesions as an adjuvant therapy.

Acne Vulgaris;Treatment;Miconazole Acne Vulgaris;Treatment;Miconazole http://www.journalssc.com/index.php?page=article&article_id=23330 Farahnaz Fatemi Farahnaz Fatemi Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran Jamshid Najafian Jamshid Najafian Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Saeid Savabi Nasab Saeid Savabi Nasab School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Ali Nilforoushzadeh Mohammad Ali Nilforoushzadeh Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Tel:+98-3133373736 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. Tel:+98-3133373736
en 10.17795/jssc27058 Traditional and Complementary Medicine, Yes or No? Traditional and Complementary Medicine, Yes or No? letter letter Medicine, Traditional;Complementary Therapies;Dermatology Medicine, Traditional;Complementary Therapies;Dermatology http://www.journalssc.com/index.php?page=article&article_id=27058 Laila Shirbeigi Laila Shirbeigi Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran; aculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98-2155693520, Fax: +98-2155693522پ Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran; aculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98-2155693520, Fax: +98-2155693522پ
en 10.17795/jssc27023 Familial Expression of Spontaneous Cervical Artery Dissections and Ehlers-Danlos Syndrome Hypermobile Type Familial Expression of Spontaneous Cervical Artery Dissections and Ehlers-Danlos Syndrome Hypermobile Type case-report case-report Conclusions

Alterations were present in both the aspect and spacing of collagen fibrils and in the shape of elastic fibers. The present familial combination of SCAD and EDSH, with almost similar ultrastructural features suggests a possible connection between both conditions.

Case Presentation

We present a woman with SCAD and her five close relatives showing obvious or suggestive signs of EDSH. In this family, the ultrastructural aspects of both diseases were closely related.

Introduction

Spontaneous cervical artery dissection (SCAD) and Ehlers-Danlos syndrome hypermobile type (EDSH) represent two heritable clinical connective tissue disorders, which show some abnormal ultrastructural features in the dermis. Genetic testing for most of those patients is not available at this time.

Conclusions

Alterations were present in both the aspect and spacing of collagen fibrils and in the shape of elastic fibers. The present familial combination of SCAD and EDSH, with almost similar ultrastructural features suggests a possible connection between both conditions.

Case Presentation

We present a woman with SCAD and her five close relatives showing obvious or suggestive signs of EDSH. In this family, the ultrastructural aspects of both diseases were closely related.

Introduction

Spontaneous cervical artery dissection (SCAD) and Ehlers-Danlos syndrome hypermobile type (EDSH) represent two heritable clinical connective tissue disorders, which show some abnormal ultrastructural features in the dermis. Genetic testing for most of those patients is not available at this time.

Skin;Collagen;Tissues;Blood Vessels;Microscopy;Electron Skin;Collagen;Tissues;Blood Vessels;Microscopy;Electron http://www.journalssc.com/index.php?page=article&article_id=27023 Trinh Hermanns-Le Trinh Hermanns-Le Unit of Electron Microscopy, Department of Dermatopathology, Unilab Lg, Liege University Hospital, Liege, Belgium Unit of Electron Microscopy, Department of Dermatopathology, Unilab Lg, Liege University Hospital, Liege, Belgium Daniel Manicourt Daniel Manicourt Rheumatology Department, Saint-Luc University Hospital, Brussels, Belgium Rheumatology Department, Saint-Luc University Hospital, Brussels, Belgium Gerald E. Pierard Gerald E. Pierard Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, Liege University, Liege, Belgium; Department of Clinical Sciences, Laboratory of Skin Bioengineering and Imaging, Liege University, B-4000 Liege, Belgium. Tel: +32-43662408 Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, Liege University, Liege, Belgium; Department of Clinical Sciences, Laboratory of Skin Bioengineering and Imaging, Liege University, B-4000 Liege, Belgium. Tel: +32-43662408
en 10.17795/jssc27108 Hand Rejuvenation by Ablative Fraction CO2 Laser Hand Rejuvenation by Ablative Fraction CO<sub>2</sub> Laser research-article research-article Objectives

This study aimed to evaluate the efficacy of AFCL in improvement of hand photoaging in 25 patients.

Patients and Methods

A prospective, before- after, single blind study was conducted in 25 patients who presented for desired treatment of hand photoaging. Patients received three treatments sessions with AFCL.

Results

All enrolled patients were female and received three treatment sessions. There was no incidence of significant adverse effects such as scarring, prolonged erythema sever edema, post inflammatory pigmentary changes, or infection. Mean improvement one month after three treatments was 48.3% (95% CI, 42.6 - 53.9) for skin wrinkling, 53.3% (95% CI, 47.9 - 58.8) for skin pigmentation, 46.9% (95% CI, 41.4 - 52.2) for skin texture, and 54.9% (95% CI, 49.3 - 60.5) for overall cosmetic outcome (all P < 0.05).

Background

Ablative fractional CO2 laser (AFCL) has been reported to be safe and effective to use for preventing hand photoaging in a recent pilot study.

Conclusions

AFCL can be used safely and effectively in the treatment of hand photoaging.

Objectives

This study aimed to evaluate the efficacy of AFCL in improvement of hand photoaging in 25 patients.

Patients and Methods

A prospective, before- after, single blind study was conducted in 25 patients who presented for desired treatment of hand photoaging. Patients received three treatments sessions with AFCL.

Results

All enrolled patients were female and received three treatment sessions. There was no incidence of significant adverse effects such as scarring, prolonged erythema sever edema, post inflammatory pigmentary changes, or infection. Mean improvement one month after three treatments was 48.3% (95% CI, 42.6 - 53.9) for skin wrinkling, 53.3% (95% CI, 47.9 - 58.8) for skin pigmentation, 46.9% (95% CI, 41.4 - 52.2) for skin texture, and 54.9% (95% CI, 49.3 - 60.5) for overall cosmetic outcome (all P < 0.05).

Background

Ablative fractional CO2 laser (AFCL) has been reported to be safe and effective to use for preventing hand photoaging in a recent pilot study.

Conclusions

AFCL can be used safely and effectively in the treatment of hand photoaging.

Hand;Rejuvenation;Photoaging of skin Hand;Rejuvenation;Photoaging of skin http://www.journalssc.com/index.php?page=article&article_id=27108 Elham Behrangi Elham Behrangi Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Zahra Azizian Zahra Azizian Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Romina Rabbani Romina Rabbani Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Hojjat Rahmanifar Hojjat Rahmanifar Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Sheida Abbasi Sheida Abbasi Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Ramin Rabbani Ramin Rabbani Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran; Iran University of Medical Sciences, Tehran, Iran. Tel: +98-9123186593 Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran; Iran University of Medical Sciences, Tehran, Iran. Tel: +98-9123186593
en 10.17795/jssc28758 Evacuation of Complicated Polyacrylamide Gel With the Help of Ultrasonographic Markings and Fat-Transfer Cannula Evacuation of Complicated Polyacrylamide Gel With the Help of Ultrasonographic Markings and Fat-Transfer Cannula research-article research-article Conclusions

Our method provided good results and performing evacuation under the guide of bedside ultrasonography is recommended.

Results

We treated 173 patients, including 164 females (94.8%), with the mean (SD) age of 43.75 (10.62) years. According to VAS, 95.4% of patients reported complete satisfaction while 2 (1.2%) were unsatisfied with the results. Patients reported no complication of therapy.

Objectives

This study aimed to introduce a new method of evacuating PAGG with the help ultrasonography markings on face.

Patients and Methods

We enrolled patients who were unsatisfied with the results of injection or had developed complications such as induration, gel migration, or infection referred to our clinic to evacuate the filler since 2011. Patients were examined by ultrasonography and a radiologist reported the volume, place, and depth of gel as well as fibrosis and marked them on the patients’ face or its photographs. We used Barikbin’s tumescent solution to facilitate the evacuation of concentrated gel and reduce the risk of injury to vital tissues. We inserted a 16G-fat-transfer cannula through a hole on the nasolabial folds and evacuated the gel by vacuum force and milking. We also used a Barikbin’s blunt subcision blade to dissect fibrosis. The evacuated region was irrigated by tumescent solution. Patients’ satisfaction was assessed by visual analogue scale (VAS). The procedure was repeated at four-week interval until achieving favorable results.

Background

Polyacrylamide gel (PAAG) has been used extensively for soft tissue augmentation. Complications of PAAG injection mandate evacuation of filler.

Conclusions

Our method provided good results and performing evacuation under the guide of bedside ultrasonography is recommended.

Results

We treated 173 patients, including 164 females (94.8%), with the mean (SD) age of 43.75 (10.62) years. According to VAS, 95.4% of patients reported complete satisfaction while 2 (1.2%) were unsatisfied with the results. Patients reported no complication of therapy.

Objectives

This study aimed to introduce a new method of evacuating PAGG with the help ultrasonography markings on face.

Patients and Methods

We enrolled patients who were unsatisfied with the results of injection or had developed complications such as induration, gel migration, or infection referred to our clinic to evacuate the filler since 2011. Patients were examined by ultrasonography and a radiologist reported the volume, place, and depth of gel as well as fibrosis and marked them on the patients’ face or its photographs. We used Barikbin’s tumescent solution to facilitate the evacuation of concentrated gel and reduce the risk of injury to vital tissues. We inserted a 16G-fat-transfer cannula through a hole on the nasolabial folds and evacuated the gel by vacuum force and milking. We also used a Barikbin’s blunt subcision blade to dissect fibrosis. The evacuated region was irrigated by tumescent solution. Patients’ satisfaction was assessed by visual analogue scale (VAS). The procedure was repeated at four-week interval until achieving favorable results.

Background

Polyacrylamide gel (PAAG) has been used extensively for soft tissue augmentation. Complications of PAAG injection mandate evacuation of filler.

Polyacrylamide Gels;Ultrasonography;Cannula;Visual Analogue Scale Polyacrylamide Gels;Ultrasonography;Cannula;Visual Analogue Scale http://www.journalssc.com/index.php?page=article&article_id=28758 Behrooz Barikbin Behrooz Barikbin Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Ehsan Abolhasani Ehsan Abolhasani Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Morteza Sanei Taheri Morteza Sanei Taheri Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hamidreza Haghighatkhah Hamidreza Haghighatkhah Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maryam Yousefi Maryam Yousefi Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Somayeh Hejazi Somayeh Hejazi Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, P. O. Box: 14176-53761, Tehran, Iran. Tel: +98-2122674977, Fax: +98-2122239264 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, P. O. Box: 14176-53761, Tehran, Iran. Tel: +98-2122674977, Fax: +98-2122239264
en 10.17795/jssc28471 Types of Stem Cells in Regenerative Medicine: A Review Types of Stem Cells in Regenerative Medicine: A Review review-article review-article

Two basic and clinical researches accomplished during the recent years on embryonic and adult stem cells constituted a mutation in regenerative therapy. These cells can be used for treating some degenerative diseases. Between them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson’s and Alzheimer’s diseases, arthritis and muscular, skin, lung, eye, and digestive disorders, aggressive and regressive cancers can be treated by cell therapies. This review focused on types of stem cells used in regenerative medicine.

Two basic and clinical researches accomplished during the recent years on embryonic and adult stem cells constituted a mutation in regenerative therapy. These cells can be used for treating some degenerative diseases. Between them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson’s and Alzheimer’s diseases, arthritis and muscular, skin, lung, eye, and digestive disorders, aggressive and regressive cancers can be treated by cell therapies. This review focused on types of stem cells used in regenerative medicine.

Stem Cell;Regenerative Medicine;Disease Stem Cell;Regenerative Medicine;Disease http://www.journalssc.com/index.php?page=article&article_id=28471 Sona Zare Sona Zare Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Soleiman Kurd Soleiman Kurd School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ayoob Rostamzadeh Ayoob Rostamzadeh Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran Mohammad Ali Nilforoushzadeh Mohammad Ali Nilforoushzadeh Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Science, Tehran, Iran. Tel: +98-2122674977, Fax: +98-2122239264 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Skin and Stem Cell Research Center, Tehran University of Medical Science, Tehran, Iran. Tel: +98-2122674977, Fax: +98-2122239264