Journal of Skin and Stem Cell Journal of Skin and Stem Cell J Skin Stem Cell http://www.journalssc.com 2423-7086 10.5812/jssc. en jalali 2017 6 23 gregorian 2017 6 23 2 3
en 10.17795/jssc35681 Injection of Autologous Fat Alone and in Combination With Autologous Platelet Gel for Nasolabial Fold Augmentation Injection of Autologous Fat Alone and in Combination With Autologous Platelet Gel for Nasolabial Fold Augmentation research-article research-article Results

All patients experienced improvement in the wrinkles of the side treated by the combination therapy compared to the other side. In addition, less complication was observed in the side that underwent combination therapy.

Conclusions

Our study showed that autologous fat in combination with platelet gel might have better cosmetic results as well as lesser complications in the healing of nasolabial wrinkles. However, the findings of this pilot study should be examined in further studies with larger sample size.

Patients and Methods

Nine volunteers (three males and six females) were referred to the dermatology clinic of Rasoul-e-Akram hospital. For each patient, one side of the lateral nasolabial folds underwent injections with the combination of autologous fat and platelet gel and the other side with autologous fat alone. Improvement of nasolabial fold was monitored by clinical assessment and digital photographs over a six-month period.

Background

Recently, soft tissue augmentation has become popular due to development of convenient techniques. Autologous fat is one of the safest fillers for this purpose. Moreover, healing effects of autologous platelet gel on acute and chronic human skin wounds have been shown in recent studies.

Objectives

In this study, the effect of subcutaneous injection of autologous fat alone and in combination with platelet gel was compared in the treatment of nasolabial skin folds in nine cases.

Results

All patients experienced improvement in the wrinkles of the side treated by the combination therapy compared to the other side. In addition, less complication was observed in the side that underwent combination therapy.

Conclusions

Our study showed that autologous fat in combination with platelet gel might have better cosmetic results as well as lesser complications in the healing of nasolabial wrinkles. However, the findings of this pilot study should be examined in further studies with larger sample size.

Patients and Methods

Nine volunteers (three males and six females) were referred to the dermatology clinic of Rasoul-e-Akram hospital. For each patient, one side of the lateral nasolabial folds underwent injections with the combination of autologous fat and platelet gel and the other side with autologous fat alone. Improvement of nasolabial fold was monitored by clinical assessment and digital photographs over a six-month period.

Background

Recently, soft tissue augmentation has become popular due to development of convenient techniques. Autologous fat is one of the safest fillers for this purpose. Moreover, healing effects of autologous platelet gel on acute and chronic human skin wounds have been shown in recent studies.

Objectives

In this study, the effect of subcutaneous injection of autologous fat alone and in combination with platelet gel was compared in the treatment of nasolabial skin folds in nine cases.

Fat Injection;Filler;Platelet Fat Injection;Filler;Platelet http://www.journalssc.com/index.php?page=article&article_id=35681 Babak Ghasemi Babak Ghasemi Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Seyed Mehdi Tabaie Seyed Mehdi Tabaie Medical Laser Research Center, ACECR, Tehran, Iran; Medical Laser Research Center, ACECR, Tehran, Iran. Tel: +98-2166402020, Fax: +98-2166402020 Medical Laser Research Center, ACECR, Tehran, Iran; Medical Laser Research Center, ACECR, Tehran, Iran. Tel: +98-2166402020, Fax: +98-2166402020 MirHadi Azizjalali MirHadi Azizjalali Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Dermatology, Hazrat-e Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran Hoda Berenjiardestani Hoda Berenjiardestani Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohammad Fereshtenejad Seyed Mohammad Fereshtenejad Firoozgar Clinical Research Development Center, Tehran University of Medical Sciences, Tehran, Iran Firoozgar Clinical Research Development Center, Tehran University of Medical Sciences, Tehran, Iran Naser Amirizadeh Naser Amirizadeh Research Center of Iranian Blood Transfusion Organization, Tehran, Iran Research Center of Iranian Blood Transfusion Organization, Tehran, Iran Mohsen Fateh Mohsen Fateh Medical Laser Research Center, ACECR, Tehran, Iran Medical Laser Research Center, ACECR, Tehran, Iran