Journal of Skin and Stem Cell Journal of Skin and Stem Cell J Skin Stem Cell http://www.journalssc.com 2423-7086 10.5812/jssc. en jalali 2017 6 28 gregorian 2017 6 28 2 3
en 10.17795/jssc30787 Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa Application of Allogeneic Fibroblast Cells in Cellular Therapy of Recessive Dystrophic Epidermolysis Bullosa review-article review-article Context

Connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. These cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body.

Evidence Acquisition

Connective tissue cells play a central role in supporting as well as repairing tissues and organs. Fibroblast cell therapy could be used for the treatment of burn wounds, scars, diabetic foot ulcers, acne scars and skin aging. This review focused on biology of fibroblasts and their role in cell therapy of recessive dystrophic epidermolysis bullosa (RDEB).

Results

Fibroblasts are known to play a pivotal role in skin structure and integrity, and dermal fibroblasts are believed to promote skin regeneration and rejuvenation via collagen production.

Conclusions

Fibroblasts can be used in transplantations to ameliorate an immune system response, in order to reduce antigen production. Human fibroblasts suppress ongoing mixed lymphocyte reactions (MLRs) between lymphocyte cells from two individuals, and supernatant materials from fibroblast cultures suppress MLRs.

Context

Connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. These cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body.

Evidence Acquisition

Connective tissue cells play a central role in supporting as well as repairing tissues and organs. Fibroblast cell therapy could be used for the treatment of burn wounds, scars, diabetic foot ulcers, acne scars and skin aging. This review focused on biology of fibroblasts and their role in cell therapy of recessive dystrophic epidermolysis bullosa (RDEB).

Results

Fibroblasts are known to play a pivotal role in skin structure and integrity, and dermal fibroblasts are believed to promote skin regeneration and rejuvenation via collagen production.

Conclusions

Fibroblasts can be used in transplantations to ameliorate an immune system response, in order to reduce antigen production. Human fibroblasts suppress ongoing mixed lymphocyte reactions (MLRs) between lymphocyte cells from two individuals, and supernatant materials from fibroblast cultures suppress MLRs.

Cell Therapy;Allogeneic Transplantation;Fibroblasts;Epidermolysis Bullosa Cell Therapy;Allogeneic Transplantation;Fibroblasts;Epidermolysis Bullosa http://www.journalssc.com/index.php?page=article&article_id=30787 Sona Zare Sona Zare Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Reza Ahmadi Reza Ahmadi Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IR Iran Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IR Iran Ayoob Rostamzadeh Ayoob Rostamzadeh Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran Soleiman Kurd Soleiman Kurd School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Somayeh Hejazi Somayeh Hejazi Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran Maryam Fard Maryam Fard Department of Anatomical Science, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran Department of Anatomical Science, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran Maryam Anjomshoa Maryam Anjomshoa Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran; Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran. Tel: +98-3813335652, Fax: +98-3813334911 Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran; Department of Anatomical Sciences, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR Iran. Tel: +98-3813335652, Fax: +98-3813334911 Mohammad Ali Nilforoushzadeh Mohammad Ali Nilforoushzadeh Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran. Tel: +98-2122674977, Fax: +98-2122239264 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran. Tel: +98-2122674977, Fax: +98-2122239264